Bayol A, Benveniste J, Brink C, Cerrina J, Gateau O, Labat C, Raffestin B
Br J Pharmacol. 1985 Jul;85(3):569-74. doi: 10.1111/j.1476-5381.1985.tb10550.x.
Responsiveness (g mm-2) and sensitivity (pD2 value) to 5-hydroxytryptamine (5-HT) were markedly reduced in isolated tracheal and bronchial tissues from guinea-pigs during ontogenesis. Responsiveness of the trachea to 5-HT was depressed much more than that to histamine. Airway preparations from young guinea-pigs of either sex always contracted when exposed to 5-HT, an effect that was blocked by methysergide. Airway muscle preparations from old animals exhibited a wide range of responses to 5-HT, namely, no effect, relaxation or contraction. The contractile effect of 5-HT in tracheal and bronchial preparations from old animals was always blocked by methysergide, whereas, the relaxant effect was not. These results indicate that there are significant alterations in the response to 5-HT receptor stimulation in airway muscle preparations from guinea-pigs during ontogenesis.
在豚鼠个体发育过程中，分离的气管和支气管组织对5-羟色胺（5-HT）的反应性（g mm-2）和敏感性（pD2值）显著降低。气管对5-HT的反应性降低程度远大于对组胺的反应性。无论雌雄，幼年豚鼠的气道标本在暴露于5-HT时总是收缩，这种效应可被麦角新碱阻断。老年动物的气道肌肉标本对5-HT表现出广泛的反应，即无效应、舒张或收缩。麦角新碱总是能阻断老年动物气管和支气管标本中5-HT的收缩效应，而对舒张效应则无阻断作用。这些结果表明，在豚鼠个体发育过程中，气道肌肉标本对5-HT受体刺激的反应存在显著改变。
