Aubineau P, Reynier-Rebuffel A M, Bouchaud C, Jousseaume O, Seylaz J
Brain Res. 1985 Jul 8;338(1):13-23. doi: 10.1016/0006-8993(85)90243-4.
The long-term effects of sympathectomy on cerebral cortical blood flow (CBF) were studied in the conscious rabbit. The quantitative, repeated measurements of blood flow were made by determination of helium clearance by mass spectrometry and were obtained simultaneously with measurements of local tissue pO2 and pCO2. Eight to 10 weeks after unilateral sympathectomy, resting blood flow in the homolateral cortex was decreased by a mean of 17% compared to the heterolateral cortex. In two animals in which blood flow was recorded both before and after the sympathectomy, the same phenomenon was observed from 8 to 30 days after the operation. The response to i.v. infusion of noradrenaline was identical in both hemispheres: doses inducing a 40% rise in blood pressure did not significantly modify CBF. The responses to angiotensin II-induced hypertension were also identical. Histochemical verifications demonstrated the effectiveness of the denervation in the pial arteries and the intraparenchymal arteries in the region studied. Thus the decrease in CBF induced by chronic sympathectomy cannot be attributed to the development of hypersensitivity to catecholamines. This decrease remained stable whatever the value of resting flow and was maintained under anesthesia. It is concluded that, as in the peripheral circulation, chronic sympathectomy affects the equilibrium of the vascular smooth muscle fibers, but that circulating amines play no compensatory role in the cerebral circulation because of the blood-brain barrier.
在清醒的兔子身上研究了交感神经切除术对大脑皮质血流（CBF）的长期影响。通过质谱法测定氦清除率对血流进行定量、重复测量，并与局部组织pO₂和pCO₂的测量同时进行。单侧交感神经切除术后8至10周，同侧皮质的静息血流比异侧皮质平均降低了17%。在两只术前和术后都记录了血流的动物中，术后8至30天观察到了相同的现象。两侧半球对静脉注射去甲肾上腺素的反应相同：使血压升高40%的剂量并未显著改变CBF。对血管紧张素II诱导的高血压的反应也相同。组织化学验证表明在所研究区域的软脑膜动脉和实质内动脉中去神经支配是有效的。因此，慢性交感神经切除术引起的CBF降低不能归因于对儿茶酚胺超敏反应的发展。无论静息血流值如何，这种降低都保持稳定，并在麻醉状态下维持。结论是，与外周循环一样，慢性交感神经切除术会影响血管平滑肌纤维的平衡，但由于血脑屏障，循环胺类在脑循环中不发挥代偿作用。
