Ayhan Yunus Emre, Özkanlı Ömer Faruk, Gözelizmir Şeyma, Al-Taie Anmar, Sancar Mesut, Midi Ipek
Clinical Pharmacy Department, Prof. Dr. Cemil Taşcıoğlu City Hospital, Istanbul, Türkiye.
Clinical Pharmacy Department, Faculty of Pharmacy, Marmara University, Istanbul, Türkiye.
Front Pharmacol. 2025 Apr 10;16:1519835. doi: 10.3389/fphar.2025.1519835. eCollection 2025.
The aim of this study was to evaluate the effects of clinical pharmacists' education and interventions on the appropriateness of dosage forms of drugs administered via the enteral feeding tubes (EFTs) in hospitalised patients in the neurology ward.
This was a prospective, pre-post intervention study conducted among patients and neurologist team professionals in the neurology ward of a training and research hospital in Istanbul, Türkiye. The study was designed in two phases as a pre-education observation period (OP) and a post-education intervention period (IP), during which the clinical pharmacists provided the required recommendations. Medications evaluated in terms of EFT-related medication administration errors (EFTRMAE) during the hospitalisation and discharge of patients in OP and IP. The knowledge levels of the neurologist team regarding EFT medication administration were collected and evaluated with an online survey before and after the education program.
A total of 68 patients were included in the study, with 34 patients in the OP and 34 in the IP. During hospitalisation, EFTRMAEs were observed in 24 patients (70.6%) in the OP, whereas in the IP, EFTRMAEs were detected in 13 patients (38.2%) before clinical pharmacist interventions (p = 0.014). Throughout hospitalisation in the IP group, clinical pharmacists provided 25 interventions related to EFTRMAEs, of which 84% were accepted by physicians. However, only 11 of the accepted recommendations were fully implemented. Following these interventions, inappropriate drug administration via EFT remained in only 5 patients (14.7%) (p < 0.001). At hospital discharge, the EFTRMAE rate, which was 76.5% in the OP group, decreased to 23.5% in the IP group (p < 0.001). The neurologist team's knowledge of EFT medication administration improved significantly following clinical pharmacist education, with the average number of correct responses increasing from 16.1 ± 4 before the education to 21.1 ± 2.1 afterward (p < 0.001).
EFTRMAEs are frequently encountered in patients hospitalised in the neurology ward. Including clinical pharmacists in the healthcare team and the education program provided to physicians and nurses will increase the knowledge level of participants and the ability of physicians to prescribe appropriate dosage forms for administration via EFT.
本研究旨在评估临床药师的教育和干预措施对神经内科住院患者经肠内喂养管（EFT）给药剂型适宜性的影响。
这是一项在土耳其伊斯坦布尔一家培训和研究医院神经内科病房的患者及神经科医生团队专业人员中进行的前瞻性干预前后对照研究。该研究分为两个阶段设计，即教育前观察期（OP）和教育后干预期（IP），在此期间临床药师提供所需建议。对OP期和IP期患者住院期间及出院时与EFT相关的用药错误（EFTRMAE）进行评估。在教育项目前后，通过在线调查收集并评估神经科医生团队关于EFT给药的知识水平。
本研究共纳入68例患者，OP期34例，IP期34例。住院期间，OP期有24例患者（70.6%）出现EFTRMAE，而在IP期，临床药师干预前有13例患者（38.2%）检测到EFTRMAE（p = 0.014）。在IP组的整个住院期间，临床药师提供了25项与EFTRMAE相关的干预措施，其中84%被医生接受。然而，只有11项被接受的建议得到了充分实施。经过这些干预后，仅5例患者（14.7%）仍存在通过EFT的不当给药情况（p < 0.001）。出院时，OP组的EFTRMAE发生率为76.5%，IP组降至23.5%（p < 0.001）。临床药师教育后，神经科医生团队对EFT给药的知识有显著提高，正确回答的平均数量从教育前的16.1 ± 4增加到教育后的21.1 ± 2.1（p < 0.001）。
神经内科住院患者中经常出现EFTRMAE。将临床药师纳入医疗团队以及为医生和护士提供教育项目将提高参与者的知识水平以及医生开具适宜经EFT给药剂型的能力。
