Jun Hogyung, Song Hyun Joo, Mun Ji Hwan, Kim Heung Up
Department of Internal Medicine, Jeju National University College of Medicine, Jeju, Korea.
Korean J Gastroenterol. 2025 Apr 25;85(2):170-178. doi: 10.4166/kjg.2024.148.
BACKGROUND/AIMS: Behcet's disease is an idiopathic, chronic, multisystemic vasculitis characterized by recurrent oral and genital ulcers, ophthalmologic inflammation, and skin lesions. This study sought to identify the involvement of the upper gastrointestinal (GI) tract in patients with Behcet's disease.
We retrospectively analyzed 365 patients diagnosed with Behcet's disease at the Jeju National University Hospital from March 2009 to 2021. GI involvement in Behcet's disease was evaluated by endoscopy. Intestinal Behcet's disease was classified according to the presence of typical intestinal ulcers, systemic Behcet's disease, and oral ulcers.
A total of 365 patients with Behcet's disease were included; 128 patients underwent endoscopy, including colonoscopy (n=80), upper endoscopy (n=115), and colonoscopy with upper endoscopy (n=68). During colonoscopy (n=80), 17 (21.3%) patients were found to have typical ulcers, 13 (16.3%) atypical ulcers, and 50 (62.5%) had no ileocolic ulcers. During upper endoscopy (n=115), upper GI involvement was found in 14 (12.2%) patients: 21.4% (3/14) in the esophagus, 35.7% (5/14) in the stomach and 42.9% (6/14) in the duodenum. Overall, among those with Behcet's disease, 10.4% (38/365) had GI involvement, with lower GI in 8.2% (30/365) and upper GI in 3.8% (14/365).
GI involvement in Behcet's disease in Jeju Island was approximately 10.4%; including lower GI involvement in 8.2% and upper GI in 3.8% of the subjects. The upper GI involvement in Behcet's disease showed typical and atypical ulcers, similar to those of the lower GI tract involvement.
背景/目的：白塞病是一种特发性、慢性、多系统血管炎，其特征为复发性口腔溃疡、生殖器溃疡、眼部炎症和皮肤病变。本研究旨在确定白塞病患者上消化道（GI）的受累情况。
我们回顾性分析了2009年3月至2021年在济州国立大学医院诊断为白塞病的365例患者。通过内镜检查评估白塞病患者的胃肠道受累情况。肠道白塞病根据典型肠道溃疡、系统性白塞病和口腔溃疡的存在情况进行分类。
共纳入365例白塞病患者；128例患者接受了内镜检查，包括结肠镜检查（n = 80）、上消化道内镜检查（n = 115）以及结肠镜联合上消化道内镜检查（n = 68）。在结肠镜检查（n = 80）中，发现17例（21.3%）患者有典型溃疡，13例（16.3%）有非典型溃疡，50例（62.5%）无回结肠溃疡。在上消化道内镜检查（n = 115）中，14例（12.2%）患者存在上消化道受累：食管受累占21.4%（3/14），胃受累占35.7%（5/14），十二指肠受累占42.9%（6/14）。总体而言，在白塞病患者中，10.4%（38/365）有胃肠道受累，其中下消化道受累占8.2%（30/365），上消化道受累占3.8%（14/365）。
济州岛白塞病患者的胃肠道受累率约为10.4%；其中下消化道受累率为8.2%，上消化道受累率为3.8%。白塞病的上消化道受累表现为典型和非典型溃疡，与下消化道受累情况相似。
