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一名儿科患者出现伴有矛盾性中性粒细胞减少的组织细胞样Sweet综合征。

Histiocytoid Sweet Syndrome With Paradoxical Neutropenia in a Pediatric Patient.

作者信息

Boock Shelby, Blannett Stacey, Jacobs Dominique, Swink Shane M

机构信息

Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA.

Division of Dermatology, Lehigh Valley Health Network, Allentown, Pennsylvania, USA.

出版信息

Pediatr Dermatol. 2025 Sep-Oct;42(5):1062-1065. doi: 10.1111/pde.15932. Epub 2025 Apr 25.

DOI:10.1111/pde.15932
PMID:40276873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12459413/
Abstract

Histiocytoid Sweet syndrome (HSS) is a rare inflammatory skin condition characterized by the infiltration of mononuclear cells in the dermis and leukocytosis with neutrophilia. This uncommon variant of classic Sweet syndrome is rarely reported in the literature, especially in pediatric patients. We present a case of an 8-month-old boy who developed idiopathic HSS along with autoimmune neutropenia. This report adds to the understanding and management of HSS with neutropenia in pediatric patients.

摘要

组织细胞样Sweet综合征（HSS）是一种罕见的炎症性皮肤病，其特征为真皮内单核细胞浸润及伴有嗜中性粒细胞增多的白细胞增多。这种经典Sweet综合征的罕见变体在文献中鲜有报道，尤其是在儿科患者中。我们报告一例8个月大的男孩，他患有特发性HSS并伴有自身免疫性中性粒细胞减少症。本报告有助于加深对儿科患者中性粒细胞减少性HSS的理解和管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfb/12459413/488fb2d55a19/PDE-42-1062-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfb/12459413/dc9fdee0ffdc/PDE-42-1062-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfb/12459413/8683974575e7/PDE-42-1062-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfb/12459413/488fb2d55a19/PDE-42-1062-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfb/12459413/dc9fdee0ffdc/PDE-42-1062-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfb/12459413/8683974575e7/PDE-42-1062-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfb/12459413/488fb2d55a19/PDE-42-1062-g001.jpg

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本文引用的文献

1
Sweet Syndrome: Clinical Features, Histopathology, and Associations of 83 Cases.Sweet综合征：83例患者的临床特征、组织病理学及相关因素
J Cutan Med Surg. 2017 May/Jun;21(3):211-216. doi: 10.1177/1203475417690719. Epub 2017 Feb 2.
2
Sweet syndrome: clinical presentation, associations, and response to treatment in 77 patients.Sweet 综合征：77 例患者的临床表现、相关因素及治疗反应。
J Am Acad Dermatol. 2013 Oct;69(4):557-64. doi: 10.1016/j.jaad.2013.06.023. Epub 2013 Jul 23.
3
Sweet syndrome with histiocytoid infiltrate and neutropenia: a rare combination.
伴有组织细胞样浸润和中性粒细胞减少的Sweet综合征：一种罕见的组合。
J Am Acad Dermatol. 2009 Nov;61(5):882-4. doi: 10.1016/j.jaad.2008.12.038. Epub 2009 Sep 6.
4
Drug-associated histiocytoid Sweet's syndrome: a true neutrophilic maturation arrest variant.药物相关性组织细胞样Sweet综合征：一种真正的中性粒细胞成熟停滞变异型。
J Cutan Pathol. 2008 Feb;35(2):220-4.
5
Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes.组织细胞样Sweet综合征：未成熟中性粒细胞的真皮浸润。
Arch Dermatol. 2005 Jul;141(7):834-42. doi: 10.1001/archderm.141.7.834.
6
Bullous Sweet's syndrome in congenital neutropenia: association with pegfilgrastim.先天性中性粒细胞减少症中的大疱性斯威特综合征：与培非格司亭的关联。
J Am Acad Dermatol. 2005 May;52(5):901-5. doi: 10.1016/j.jaad.2004.12.028.
7
Familial Sweet's syndrome in 2 brothers, both seen in the first 2 weeks of life.两兄弟患家族性斯威特综合征，均在出生后前两周内发病。
J Am Acad Dermatol. 2003 Jul;49(1):132-8. doi: 10.1067/mjd.2003.328.
8
Sweet syndrome in a child with aplastic anemia receiving recombinant granulocyte colony-stimulating factor.一名再生障碍性贫血患儿在接受重组粒细胞集落刺激因子治疗时发生Sweet综合征。
J Pediatr Hematol Oncol. 1996 Aug;18(3):282-4. doi: 10.1097/00043426-199608000-00009.