Wendt J S
Brain Res Bull. 1985 Jul;15(1):13-8. doi: 10.1016/0361-9230(85)90055-3.
Gelfoam treated with peripheral nerve homogenate was implanted into a site of hippocampal fimbria transection in the adult rat to assess whether the homogenate might enhance growth of AChE-positive fibers into the lesion site and whether the fiber growth might be directed to the implants. Homogenate was prepared from intact peripheral nerve and in a few cases from degenerated nerve. Some implants were encased in Silastic. Homogenate was also injected into the denervated hippocampus. The major finding was that AChE-positive fiber growth was associated with regions of high astroglial cell content in preference to the relatively hypocellular implants. No clear differences in AChE fiber sprouting into the lesion site, fiber growth into implants, or hippocampal reinnervation were noted between homogenate and saline-treated animals.
将用周围神经匀浆处理过的明胶海绵植入成年大鼠海马伞横断部位，以评估匀浆是否能促进乙酰胆碱酯酶（AChE）阳性纤维向损伤部位生长，以及纤维生长是否会朝向植入物。匀浆由完整的周围神经制备，少数情况下由退变神经制备。一些植入物用硅橡胶包裹。匀浆也被注入失神经支配的海马。主要发现是，AChE阳性纤维生长与星形胶质细胞含量高的区域相关，而非细胞相对较少的植入物。在匀浆处理组和生理盐水处理组动物之间，未观察到AChE纤维向损伤部位的芽生、纤维向植入物的生长或海马再支配方面的明显差异。
