纳米颗粒铜簇介导的心脏生物分子标志物的生物传感

Nanoparticulate Copper Cluster-Mediated Biosensing of Cardiac Biomolecular Markers.

作者信息

Nair Lakshmi V, Wheeler Jarred, Ha Yaelyn, Jones Kimberly M, Jones Jesse, Thomas Vinoy

机构信息

Department of Mechanical and Materials Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Department of Neurosurgery, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

出版信息

Biosensors (Basel). 2025 Apr 8;15(4):237. doi: 10.3390/bios15040237.

DOI:10.3390/bios15040237

PMID:40277550

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12025221/

Abstract

Being a leading cause of death, heart diseases across the globe need special attention to enable early diagnosis. Metal nanoparticle-mediated biosensors are useful clinical tools for the early detection of bio-analytes. The size-dependent surface plasmon resonance (SPR) of metal nanoparticles can be effectively utilized for the same purpose. The early detection of heart diseases can be evaluated by monitoring the troponin level. A copper nanoparticle-mediated troponin biosensor was developed through antibody conjugation for troponin I and troponin T. The copper nanosensor shows a concentration-dependent SPR change towards troponin T and troponin I.

摘要

作为全球主要死因之一，心脏病需要特别关注以实现早期诊断。金属纳米颗粒介导的生物传感器是用于生物分析物早期检测的有用临床工具。金属纳米颗粒的尺寸依赖性表面等离子体共振（SPR）可有效地用于同一目的。心脏病的早期检测可通过监测肌钙蛋白水平来评估。通过与肌钙蛋白I和肌钙蛋白T进行抗体偶联，开发了一种铜纳米颗粒介导的肌钙蛋白生物传感器。该铜纳米传感器显示出对肌钙蛋白T和肌钙蛋白I的浓度依赖性SPR变化。