De Martino Lucia, Piga Patrizia, Sessa Marcella, Calì Camilla, Russo Camilla, Picariello Stefania, Onorini Nicola, Spennato Pietro, Quaglietta Lucia, Donofrio Maria Vittoria, Cinalli Giuseppe, Vetrano Francesco, Savoia Fabio
Neurooncology Unit, Department of Pediatric Oncology, Santobono-Pausilipon Children's Hospital, 80129 Naples, Italy.
Childhood Cancer Registry of Campania, Santobono-Pausilipon Children's Hospital, 80129 Naples, Italy.
Curr Oncol. 2025 Apr 10;32(4):222. doi: 10.3390/curroncol32040222.
Oncological care of adolescent patients is often inconsistent, as they frequently fall between pediatric and adult services. The Childhood Cancer Registry of Campania (CCRC) is the Italian largest population-based registry specializing in children 0-19 years old, with a target population of approximately 1.1 million inhabitants.
This report presents epidemiological indicators and clinical pathways on primary brain tumors in adolescents (15-19 years) from the Campania region.
Over the study period (2008-2020), the cohort included 219 adolescents with newly diagnosed central nervous system (CNS) tumors with an annual average incidence rate (IR) of 48.9 cases per million/year. The 5-year observed survival rate after diagnosis of CNS tumor was 84.8%. Overall, the most common tumor site was the pituitary gland and craniopharyngeal duct, representing 22.4% of all tumors. The most frequently occurring malignant primary CNS tumor was germinoma, while the most common non-malignant tumor was pituitary adenoma. Most patients were referred to adult services and nearly half migrated outside the region to receive cancer care.
Challenges in the care of adolescent oncology patients include limited access to specialized care, difficulties in transitioning from pediatric to adult institutions, distinct tumor biology, and the underrepresentation of adolescents in clinical trials. The care of adolescents with CNS tumors is fragmented across institutions and significant variations in practice exist between adult and pediatric practitioners.
青少年患者的肿瘤护理往往不一致，因为他们常常处于儿科和成人医疗服务之间的空白地带。坎帕尼亚儿童癌症登记处（CCRC）是意大利最大的基于人群的登记处，专门针对0至19岁的儿童，目标人群约为110万居民。
本报告展示了坎帕尼亚地区青少年（15至19岁）原发性脑肿瘤的流行病学指标和临床路径。
在研究期间（2008 - 2020年），该队列包括219名新诊断为中枢神经系统（CNS）肿瘤的青少年，年平均发病率（IR）为每百万/年48.9例。CNS肿瘤诊断后的5年观察生存率为84.8%。总体而言，最常见的肿瘤部位是垂体和颅咽管，占所有肿瘤的22.4%。最常发生的恶性原发性CNS肿瘤是生殖细胞瘤，而最常见的非恶性肿瘤是垂体腺瘤。大多数患者被转诊至成人医疗服务机构，近一半患者跨地区前往其他地方接受癌症治疗。
青少年肿瘤患者护理面临的挑战包括获得专科护理的机会有限、从儿科机构向成人机构过渡困难、独特的肿瘤生物学特性以及青少年在临床试验中的代表性不足。中枢神经系统肿瘤青少年患者的护理在各机构之间分散，成人和儿科从业者的实践存在显著差异。
