西班牙原发性恶性和非恶性中枢神经肿瘤的描述性流行病学：赫罗纳癌症登记处的结果（1994 - 2013年）

Descriptive epidemiology of primary malignant and non-malignant central nervous tumors in Spain: Results from the Girona Cancer Registry (1994-2013).

作者信息

Fuentes-Raspall Rafael, Solans Marta, Roca-Barceló Aina, Vilardell Loreto, Puigdemont Montse, Del Barco Sonia, Comas Raquel, García-Velasco Adelaida, Astudillo Aurora, Carmona-Garcia Mª Carme, Marcos-Gragera Rafael

机构信息

Radiation Oncology Service, Josep Trueta University Hospital, Catalan Institute of Oncology, Avinguda de França, S/N, 17007 Girona, Spain.

CIBER in Epidemiology and Public Health (CIBERESP), University of Girona (UdG), C/ Universitat de Girona 10,17003 Girona, Spain, Spain; Research Group on Statistics, Econometrics and Health (GRECS), University of Girona (UdG), C/ Universitat de Girona 10,17003 Girona, Spain; Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Carrer del Sol, 15, 17004 Girona, Spain.

出版信息

Cancer Epidemiol. 2017 Oct;50(Pt A):1-8. doi: 10.1016/j.canep.2017.07.005. Epub 2017 Jul 21.

DOI:10.1016/j.canep.2017.07.005

PMID:28738268

Abstract

BACKGROUND

Systematic registration of non-malignant central nervous system (CNS) tumors is a rare practice among European cancer registries. Thus, the real burden of all CNS tumors across Europe is underestimated. The Girona Cancer Registry provides here the first data on CNS tumor incidence and survival trends in Spain for all histological types, including malignant and non-malignant tumors.

METHODS

Data on all incident cases of primary CNS tumors notified to the Girona population-based cancer registry from 1994 to 2013 (n=2,131) were reviewed. Incidences rates (IRs) were standardized to the 2013 European population and annual percentage changes (EAPC) were estimated using a piecewise log linear model. 1- and 5-year observed (OS) and relative survival (RS) were also calculated. Results were expressed by sex, age-group, histological subtype and behavior.

RESULTS

The overall IR was 16.85 and increased across the period of study (EAPC=+2.2%). The proportion and IRs of malignant (50.2%; IR=9.35) and non-malignant cases (49.8%; IR=9.14) were similar; however, non-malignant tumors were more frequent in women (sex ratio=0.63). The most frequently reported histologies were meningioma (27.6%; IR=5.11) and glioblastoma (22.2%; IR=4.15), which also accounted for the highest and lowest 5-year RS (80.2%; 3.7%, respectively). Globally, 5-year RS was lower in men (42.6% vs. 58.3%, respectively) and in the elderly (64.9% for 0-14years vs. 23.0% for >74years).

CONCLUSION

This study presents a comprehensive overview of the epidemiology of malignant and non-malignant CNS primary tumors from the well-established region-wide Girona Cancer Registry (1994-2013). Incidence rates were recovered for all histologies. Survival is still dramatically associated to both age and histological subtype.

摘要

背景

在欧洲癌症登记处中，对非恶性中枢神经系统（CNS）肿瘤进行系统登记的做法很少见。因此，整个欧洲所有中枢神经系统肿瘤的实际负担被低估了。赫罗纳癌症登记处在此提供了西班牙所有组织学类型（包括恶性和非恶性肿瘤）的中枢神经系统肿瘤发病率和生存趋势的首批数据。

方法

回顾了1994年至2013年通知给赫罗纳基于人群的癌症登记处的所有原发性中枢神经系统肿瘤发病病例的数据（n = 2,131）。发病率（IRs）根据2013年欧洲人口进行标准化，并使用分段对数线性模型估计年度百分比变化（EAPC）。还计算了1年和5年观察生存率（OS）和相对生存率（RS）。结果按性别、年龄组、组织学亚型和行为进行表达。

结果

总体发病率为16.85，并在研究期间有所上升（EAPC = +2.2%）。恶性病例（50.2%；IR = 9.35）和非恶性病例（49.8%；IR = 9.14）的比例和发病率相似；然而，非恶性肿瘤在女性中更为常见（性别比 = 0.63）。最常报告的组织学类型是脑膜瘤（27.6%；IR = 5.11）和胶质母细胞瘤（22.2%；IR = 4.15），它们的5年相对生存率也分别是最高和最低（分别为80.2%；3.7%）。总体而言，男性的5年相对生存率较低（分别为42.6%对58.3%），老年人也是如此（0 - 14岁为64.9%，>74岁为23.0%）。