Diaz Juan Pablo, Pena Eduardo, El Alam Samia, Matte Cecilia, Cortés Isaac, Figueroa Leonardo, Siques Patricia, Brito Julio
Faculty of Natural and Renewable Resources, Arturo Prat University, Iquique 1100000, Chile.
Núcleo de Investigación Aplicada e Innovación en Ciencias Biológicas, Facultad de Recursos Naturales Renovables, Universidad Arturo Prat, Iquique 1110939, Chile.
Toxics. 2025 Apr 18;13(4):313. doi: 10.3390/toxics13040313.
Lead is a harmful heavy metal known to alter the environment and affect human health. Several industries have contributed to the increase in lead contamination, making it a major global concern. Thus, remediation strategies are necessary to prevent lead bioaccumulation and deleterious health effects. The aim of this study was to determine the capacity of the green microalga ( or CV) to remove lead in an animal model and prevent the accumulation of this heavy metal in the principal organs (brain, liver, and kidney) and blood. Forty male Wistar rats were randomly assigned to four groups (n = 10): control group (CT); supplementation group, 5% of the diet (CV); lead acetate administration group, 500 ppm (Pb); and supplementation group, 5% of the diet plus lead acetate administration group, 500 ppm (CV-Pb). After 4 weeks of exposure, we measured lead accumulation, memory function, oxidative stress, and antioxidant activity (SOD and GSH). Lead exposure altered memory function, increased oxidative stress in the brain and kidney, and increased SOD activity in the brain. Supplementation with restored memory function to control levels; reduced oxidative stress in the brain and kidney; and decreased the accumulation of lead in the liver, kidney, and blood of rats exposed to lead. Based on our results, is a lead chelating and antioxidant agent in animal models.
铅是一种已知会改变环境并影响人类健康的有害重金属。多个行业导致了铅污染的增加，使其成为一个主要的全球问题。因此，需要采取修复策略来防止铅的生物累积和有害的健康影响。本研究的目的是确定绿色微藻（或CV）在动物模型中去除铅的能力，并防止这种重金属在主要器官（脑、肝和肾）和血液中蓄积。将40只雄性Wistar大鼠随机分为四组（n = 10）：对照组（CT）；饮食中添加5%（CV）的补充组；醋酸铅给药组，500 ppm（Pb）；以及饮食中添加5%且醋酸铅给药组，500 ppm（CV-Pb）。暴露4周后，我们测量了铅蓄积、记忆功能、氧化应激和抗氧化活性（超氧化物歧化酶和谷胱甘肽）。铅暴露改变了记忆功能，增加了脑和肾中的氧化应激，并增加了脑中的超氧化物歧化酶活性。补充CV使记忆功能恢复到对照水平；降低了脑和肾中的氧化应激；并减少了铅暴露大鼠肝、肾和血液中的铅蓄积。基于我们的结果，CV在动物模型中是一种铅螯合剂和抗氧化剂。
