da Silva Cavalcanti Jonathan França, da Fonseca Silveira Márcia Maria, da Silva Weslay Rodrigues, Dos Santos Rebeka Thiara Nascimento, Camargo Igor Batista, Sobral Ana Paula Veras
Department of Oral and Maxillofacial Pathology, School of Dentistry, Postgraduate Program in Dentistry, Universidade de Pernambuco (UPE), Recife, Pernambuco, Brazil.
Hospital Universitário Oswaldo Cruz (HUOC), Integrated Anatomic Pathology Center, Recife, Pernambuco, Brazil.
Head Neck Pathol. 2025 Apr 25;19(1):44. doi: 10.1007/s12105-025-01781-3.
Chondrosarcoma is a malignant neoplasm characterized by the production of a cartilaginous matrix.
We present the case of a 58-year-old male patient referred to the maxillofacial surgery and traumatology service due to swelling in the posterior region of the right maxilla, with a duration of 8 months, and a previous history of a fibro-osseous lesion in the region. Intraoral examination revealed a rounded lesion with ulceration, firm upon palpation, in the area of teeth 17 and 18. The panoramic radiograph revealed a radiopaque lesion with a flocculated pattern in the right maxilla, and computed tomography showed a hyperdense lesion containing hypodense areas. Histopathological analysis revealed the presence of immature cartilage, with rounded neoplastic cells, nuclei of varied sizes, and intense pleomorphism, leading to a diagnosis of chondrosarcoma. The patient underwent surgical resection followed by radiotherapy and, after one year of follow-up, has shown no signs of recurrence.
Although rare in gnathic bones, chondrosarcoma should be considered in the differential diagnosis of osseous enlargement in this region.
软骨肉瘤是一种以产生软骨基质为特征的恶性肿瘤。
我们报告一例58岁男性患者，因右上颌后部肿胀8个月就诊于颌面外科和创伤科，该区域既往有纤维骨病变史。口腔检查发现17和18牙区域有一个圆形溃疡病变，触诊质地坚硬。全景X线片显示右上颌有一个呈絮状的不透光病变，计算机断层扫描显示一个高密度病变，内有低密度区域。组织病理学分析显示存在未成熟软骨，有圆形肿瘤细胞，细胞核大小不一，且有明显的多形性，诊断为软骨肉瘤。患者接受了手术切除，随后进行了放疗，随访一年后未出现复发迹象。
尽管软骨肉瘤在颌骨中罕见，但在该区域骨质增大的鉴别诊断中应考虑到。
