Epstein F
Cancer. 1985 Oct 1;56(7 Suppl):1804-6. doi: 10.1002/1097-0142(19851001)56:7+<1804::aid-cncr2820561316>3.0.co;2-5.
Intrinsic brain stem neoplasms are almost invariably malignant, and irrespective of radiation treatment and chemotherapy, are associated with a very abbreviated survival. It is possible that occasional long-term survival is the result of a radiation-sensitive low-grade astrocytoma. It is suggested that a primary staging system may separate poor-risk and good-risk patient populations and that this classification may be important in assessing future therapeutic options.