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Plasmalogen. Quo vadis?

作者信息

Watschinger Katrin

机构信息

Institute of Molecular Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.

出版信息

J Lipid Res. 2025 Jun;66(6):100814. doi: 10.1016/j.jlr.2025.100814. Epub 2025 Apr 23.

DOI:10.1016/j.jlr.2025.100814

PMID:40280280

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12149575/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f73/12149575/d52d4e446307/gr1.jpg

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Modulation of endogenous plasmalogens by genetic ablation of lysoplasmalogenase (Tmem86b) in mice.

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Functional characterization of TMEM86A and TMEM86B mutants by a novel lysoplasmalogenase assay.

J Lipid Res. 2025 Apr;66(4):100766. doi: 10.1016/j.jlr.2025.100766. Epub 2025 Feb 28.

Regulation of plasmalogen metabolism and traffic in mammals: The fog begins to lift.

Front Cell Dev Biol. 2022 Aug 31;10:946393. doi: 10.3389/fcell.2022.946393. eCollection 2022.

Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism.

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Each phospholipase A type exhibits distinct selectivity toward sn-1 ester, alkyl ether, and vinyl ether phospholipids.

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Coenzyme-A-Independent Transacylation System; Possible Involvement of Phospholipase A2 in Transacylation.

Biology (Basel). 2017 Mar 30;6(2):23. doi: 10.3390/biology6020023.

Functions of plasmalogen lipids in health and disease.

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Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen.

J Biol Chem. 2011 Jul 15;286(28):24916-30. doi: 10.1074/jbc.M111.247163. Epub 2011 Apr 22.

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Front Microbiol. 2024 Sep 13;15:1460335. doi: 10.3389/fmicb.2024.1460335. eCollection 2024.

本文引用的文献

Modulation of endogenous plasmalogens by genetic ablation of lysoplasmalogenase (Tmem86b) in mice.

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Functional characterization of TMEM86A and TMEM86B mutants by a novel lysoplasmalogenase assay.

J Lipid Res. 2025 Apr;66(4):100766. doi: 10.1016/j.jlr.2025.100766. Epub 2025 Feb 28.

Regulation of plasmalogen metabolism and traffic in mammals: The fog begins to lift.

Front Cell Dev Biol. 2022 Aug 31;10:946393. doi: 10.3389/fcell.2022.946393. eCollection 2022.

Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism.

Nat Commun. 2022 Jul 14;13(1):4084. doi: 10.1038/s41467-022-31805-3.

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