Mutwalli Hiba, Herle Moritz, Kan Carol, Keeler Johanna L, Steves Claire, Treasure Janet, Himmerich Hubertus, Thompson Ellen J
Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Department of Clinical Nutrition, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
J Affect Disord. 2025 Aug 1;382:264-273. doi: 10.1016/j.jad.2025.04.111. Epub 2025 Apr 23.
The extent to which depression impacts eating behaviours, and the mechanisms underpinning their relationship are unclear. We aim to investigate the relationship between depression diagnosis and eating behaviours.
We analysed data from 1426 participants of the twins UK registry, which includes 722 monozygotic (MZ) and 702 dizygotic (DZ) twins. Eating behaviours were measured using the three-factor eating questionnaire while depression and antidepressant usage were self-reported. Co-twin control design was used to model the association between depression and eating. Sensitivity tests were implemented to exclude those using antidepressants.
The heritability estimates for eating behaviours were between 35 and 41 %. Twins with a history of depression had higher scores on the emotional (d = -0.31) and constrained eating (d = -0.18). The intraclass correlations revealed a higher covariation in MZ compared to DZ twins. A moderate relationship was observed between lifetime depression and uncontrolled (β = 0.61, 95 % CI [0.17; 1.06]), emotional (β = 0.38, 95 % CI [0.22; 0.55]) and restrained eating (β = 0.43, 95 % CI [0.10; 0.77]). After removing those on antidepressants (n = 195), the relationship between eating and depression attenuated, indicating a potential influence of antidepressants in this association.
Our findings suggest the association between depression and eating can be partly explained by pre-existing genetic and environmental vulnerabilities. Understanding the mechanisms underlying this relationship could guide the development of effective management strategies, including personalized nutrition plans, integrated mental and dietary care, and regular monitoring to mitigate the risk of maladaptive eating behaviours and eating disorders.
抑郁症对饮食行为的影响程度及其关系背后的机制尚不清楚。我们旨在研究抑郁症诊断与饮食行为之间的关系。
我们分析了来自英国双胞胎登记处1426名参与者的数据，其中包括722对同卵双胞胎（MZ）和702对异卵双胞胎（DZ）。使用三因素饮食问卷测量饮食行为，而抑郁症和抗抑郁药物使用情况则通过自我报告获得。采用同卵双胞胎对照设计来模拟抑郁症与饮食之间的关联。实施敏感性测试以排除使用抗抑郁药物的人群。
饮食行为的遗传度估计在35%至41%之间。有抑郁症病史的双胞胎在情绪性饮食（d = -0.31）和克制性饮食（d = -0.18）方面得分更高。组内相关性显示，同卵双胞胎比异卵双胞胎的协变量更高。观察到终生抑郁症与无节制饮食（β = 0.61，95%置信区间[0.17；1.06]）、情绪性饮食（β = 0.38，95%置信区间[0.22；0.55]）和克制性饮食（β = 0.43，95%置信区间[0.10；0.77]）之间存在中等程度的关系。在排除使用抗抑郁药物的人群（n = 195）后，饮食与抑郁症之间的关系减弱，表明抗抑郁药物在这种关联中可能存在潜在影响。
我们的研究结果表明，抑郁症与饮食之间的关联部分可由先前存在的遗传和环境易感性来解释。了解这种关系背后的机制可以指导制定有效的管理策略，包括个性化营养计划、综合心理和饮食护理以及定期监测，以降低不良饮食行为和饮食失调的风险。
