Argyri Smaragda-Maria, Svenningsson Leo, Guerroudj Feryal, Bernin Diana, Evenäs Lars, Bordes Romain
Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Nat Commun. 2025 Apr 25;16(1):3917. doi: 10.1038/s41467-025-58949-2.
Conventional magnetic resonance measurements often rely on the use of sample containers. This limits the implementation of time-resolved studies at the molecular level of liquid samples undergoing evaporation or other dynamic phenomena that require access to the liquid-gas interface. In this study, we developed a demagnetized acoustic levitator to perform magnetic resonance studies on liquid samples, in a contact-free manner. The performance of the levitator inside a 7.05 T magnetic field was examined and magnetic resonance images of the levitator and the levitated samples were acquired. Then, we collected magnetic resonance spectra of the levitated droplets by applying localized and non-localized pulse sequences and we examined the effect of the droplet shape on the chemical shift. Additionally, we conducted time-resolved experiments on pure solvents and mixtures, and captured physical and chemical molecular interactions, in real-time. This approach enables contact-free studies at the molecular level of dynamic phenomena on a microliter droplet using magnetic resonance techniques.
传统的磁共振测量通常依赖于使用样品容器。这限制了在分子水平上对经历蒸发或其他需要接触液-气界面的动态现象的液体样品进行时间分辨研究。在本研究中，我们开发了一种去磁声悬浮器，以无接触方式对液体样品进行磁共振研究。研究了该悬浮器在7.05 T磁场中的性能，并采集了悬浮器和悬浮样品的磁共振图像。然后，我们通过应用局部和非局部脉冲序列收集了悬浮液滴的磁共振谱，并研究了液滴形状对化学位移的影响。此外，我们对纯溶剂和混合物进行了时间分辨实验，并实时捕捉了物理和化学分子相互作用。这种方法能够使用磁共振技术在微升液滴的分子水平上对动态现象进行无接触研究。
