Siu Wing Sum, Ma Hui, Leung Ping Chung
Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
Bioengineering (Basel). 2025 Apr 18;12(4):428. doi: 10.3390/bioengineering12040428.
Burns are common injuries, but their treatment remains challenging due to the complex nature of the wound healing process. Burn wounds are classified into different categories based on their size and depth. Treatment modalities vary significantly across these categories, primarily focusing on the inflammation, proliferation, and remodeling phases of burn wound healing. This review summarizes current research on various approaches to enhance burn wound recovery, including advancements in wound dressings, the use of platelet-rich plasma, stem cells, their soluble factors primarily in the form of secretomes or extracellular vesicles, and nano-technologies. Additionally, advancements in modernized traditional medicine are discussed to give a new aspect for burn wound healing. This review also summarizes the barriers in translating bench research to clinical practice in burn wound treatment methods. For an effective translation, researchers and industrial partners should work more closely, while regulatory bodies should streamline the approval procedure.
烧伤是常见的损伤,但由于伤口愈合过程的复杂性,其治疗仍然具有挑战性。烧伤创面根据其大小和深度分为不同类别。这些类别的治疗方式差异很大,主要集中在烧伤创面愈合的炎症、增殖和重塑阶段。本综述总结了目前关于促进烧伤创面恢复的各种方法的研究,包括伤口敷料的进展、富含血小板血浆、干细胞、主要以分泌组或细胞外囊泡形式存在的其可溶性因子以及纳米技术的应用。此外,还讨论了现代传统医学的进展,为烧伤创面愈合提供了新的视角。本综述还总结了烧伤创面治疗方法从实验室研究转化为临床实践的障碍。为了实现有效的转化,研究人员和产业合作伙伴应更紧密地合作,而监管机构应简化审批程序。
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