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烧伤创面愈合促进的当前进展综述

Review on Current Advancements in Facilitation of Burn Wound Healing.

作者信息

Siu Wing Sum, Ma Hui, Leung Ping Chung

机构信息

Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

出版信息

Bioengineering (Basel). 2025 Apr 18;12(4):428. doi: 10.3390/bioengineering12040428.


DOI:10.3390/bioengineering12040428
PMID:40281787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12024970/
Abstract

Burns are common injuries, but their treatment remains challenging due to the complex nature of the wound healing process. Burn wounds are classified into different categories based on their size and depth. Treatment modalities vary significantly across these categories, primarily focusing on the inflammation, proliferation, and remodeling phases of burn wound healing. This review summarizes current research on various approaches to enhance burn wound recovery, including advancements in wound dressings, the use of platelet-rich plasma, stem cells, their soluble factors primarily in the form of secretomes or extracellular vesicles, and nano-technologies. Additionally, advancements in modernized traditional medicine are discussed to give a new aspect for burn wound healing. This review also summarizes the barriers in translating bench research to clinical practice in burn wound treatment methods. For an effective translation, researchers and industrial partners should work more closely, while regulatory bodies should streamline the approval procedure.

摘要

烧伤是常见的损伤,但由于伤口愈合过程的复杂性,其治疗仍然具有挑战性。烧伤创面根据其大小和深度分为不同类别。这些类别的治疗方式差异很大,主要集中在烧伤创面愈合的炎症、增殖和重塑阶段。本综述总结了目前关于促进烧伤创面恢复的各种方法的研究,包括伤口敷料的进展、富含血小板血浆、干细胞、主要以分泌组或细胞外囊泡形式存在的其可溶性因子以及纳米技术的应用。此外,还讨论了现代传统医学的进展,为烧伤创面愈合提供了新的视角。本综述还总结了烧伤创面治疗方法从实验室研究转化为临床实践的障碍。为了实现有效的转化,研究人员和产业合作伙伴应更紧密地合作,而监管机构应简化审批程序。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b15c/12024970/90a149790937/bioengineering-12-00428-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b15c/12024970/90a149790937/bioengineering-12-00428-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b15c/12024970/90a149790937/bioengineering-12-00428-g001.jpg

相似文献

[1]
Review on Current Advancements in Facilitation of Burn Wound Healing.

Bioengineering (Basel). 2025-4-18

[2]
[Clinical study of cell sheets containing allogeneic keratinocytes and fibroblasts for the treatment of partial-thickness burn wounds].

Zhonghua Shao Shang Za Zhi. 2020-3-20

[3]
Treatment of superficial and deep partial width second degree burn's wound with allogeneic cord blood platelet gel.

Skin Res Technol. 2023-9

[4]
[A cross-sectional investigation and analysis of early treatment of partial-thickness burn wounds by professional burn medical staff in China].

Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022-6-20

[5]
Nanoengineered Therapeutic Scaffolds for Burn Wound Management.

Curr Pharm Biotechnol. 2022

[6]
Severe Burn Injury in a Swine Model for Clinical Dressing Assessment.

J Vis Exp. 2018-11-6

[7]
Bioactive peptide amphiphile nanofiber gels enhance burn wound healing.

Burns. 2019-4-28

[8]
Preparation of self-regulating/anti-adhesive hydrogels and their ability to promote healing in burn wounds.

J Biomed Mater Res B Appl Biomater. 2018-10-8

[9]
Functional Hydrogel Dressings for Treatment of Burn Wounds.

Front Bioeng Biotechnol. 2021-12-6

[10]
Polymer-based Nanotherapeutics for Burn Wounds.

Curr Pharm Biotechnol. 2022

本文引用的文献

[1]
Time trends in thermal burns incidence among Brazil, Russia, India, China, and South Africa (BRICS), an age-period-cohort analysis from the GBD 2019.

Sci Rep. 2025-2-26

[2]
Epidermal stem cell-derived exosomes improve wound healing by promoting the proliferation and migration of human skin fibroblasts.

Burns Trauma. 2024-12-16

[3]
Exploring the therapeutic potential of different sources of mesenchymal stem cells: a novel approach to combat burn wound infections.

Front Microbiol. 2024-11-29

[4]
The Wound-Healing Effect of a Novel Fibroblasts-Impregnated Hydroxyethylcellulose Gel in a Rat Full-Thickness Burn Model: A Preclinical Study.

Biomedicines. 2024-9-28

[5]
Exosomes from mesenchymal stem cells: Potential applications in wound healing.

Life Sci. 2024-11-15

[6]
Burn Wound Healing Activity of Hydroxyethylcellulose Gels with Different Water Extracts Obtained from Various Medicinal Plants in -Infected Rabbits.

Int J Mol Sci. 2024-8-18

[7]
Electrospun nanofibers synthesized from polymers incorporated with bioactive compounds for wound healing.

J Nanobiotechnology. 2024-4-27

[8]
Effects of Aloe vera on Burn Injuries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Burn Care Res. 2024-11-14

[9]
A critical overview of challenging roles of medicinal plants in improvement of wound healing technology.

Daru. 2024-6

[10]
Fabrication of bioinspired keratin/sodium alginate based biopolymeric mat loaded with herbal drug and green synthesized zinc oxide nanoparticles as a dual drug antimicrobial wound dressing.

Int J Biol Macromol. 2024-2

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