Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Skin Repair Research Center, Jordan Dermatology and Hair Transplantation Center, Tehran, Iran.
Skin Res Technol. 2023 Sep;29(9):e13471. doi: 10.1111/srt.13471.
Burns are caused by a variety of mechanisms, including flames, hot liquids, metallurgy, chemicals, electric current, and ionizing and non-ionizing radiation. The most significant burn wound management involves complete repair and regeneration as soon as possible while minimizing infection, contraction, and scarring in the damaged tissue area. Some factors such as delivery of nutrients, growth factors, and oxygen are essential to promote and stimulate the wound healing progress in the burns area. When these factors are not provided, the burn wound undergoes a physiological crisis. The use of growth factors is a promising approach to overcoming this limitation. Umbilical cord blood platelet concentrates are a rich natural source of growth factors.
This clinical trial used growth factors released from the lysis of umbilical cord blood platelet concentrates that have a key role in promoting re-epithelization and regeneration of damaged tissues by forming a fibrin network. This study evaluated the effectiveness of allogeneic cord blood platelet gel topical dressing in a group of patients diagnosed with superficial and deep partial thickness (second-degree) burn wounds. Clinical outcomes were compared between the intervention group and a control group of patients with superficial second-degree burn wounds who received the standard routine treatment including paraffin gauze wound dressing and silver sulfadiazine ointment.
The study's results showed that the increased rate of recovery and tissue granulation completely promoted to wound healing and burn wound closure, decreased the recovery time, and reduced inflammation and scars caused by burn injuries. However, the use of cord blood platelet gel topical dressing is not currently a routine treatment method in patients suffering from burn wounds. However, the study's results showed that allogenic cord blood platelet gel could be used to treat superficial and deep second-degree burns as a routine treatment. It was also shown that allogenic cord blood platelet gel topical dressing could be a candidate for autograft or after autograft skin transplantation surgery (in donor and recipient sites) instead of skin surgery in some patients.
Allogeneic topical wound dressing provides an effective treatment that offers a faster rate of epithelialization and healing of wounds and also decreases patients' scar and inflammation level as well as the length of recovery time. This, finally, leads to better burn wound management and the improved quality of burn wound treatment.
烧伤是由多种机制引起的，包括火焰、热液、冶金、化学物质、电流以及电离和非电离辐射。最重要的烧伤创面处理方法是尽快完成创面的完全修复和再生，同时将感染、收缩和瘢痕形成最小化。一些因素，如营养物质、生长因子和氧气的输送，对于促进和刺激烧伤区域的伤口愈合过程是必不可少的。当这些因素得不到满足时，烧伤创面会经历生理危机。生长因子的应用是克服这一限制的一种有前途的方法。脐带血血小板浓缩物是富含生长因子的天然来源。
本临床试验使用从脐带血血小板浓缩物溶解中释放的生长因子，这些生长因子在通过形成纤维蛋白网络促进受损组织的再上皮化和再生方面起着关键作用。本研究评估了同种异体脐带血血小板凝胶局部敷料在一组诊断为浅Ⅱ度和深Ⅱ度部分厚度（浅Ⅱ度）烧伤患者中的疗效。干预组和一组接受常规治疗（包括石蜡纱布创面敷料和磺胺嘧啶银软膏）的浅Ⅱ度烧伤患者的对照组之间的临床结果进行了比较。
研究结果表明，恢复和组织肉芽形成的增长率完全促进了伤口愈合和烧伤创面闭合，缩短了恢复时间，并减少了烧伤引起的炎症和瘢痕。然而，脐带血血小板凝胶局部敷料的使用目前不是烧伤患者的常规治疗方法。然而，研究结果表明，同种异体脐带血血小板凝胶可作为常规治疗方法用于治疗浅Ⅱ度和深Ⅱ度烧伤。研究还表明，同种异体脐带血血小板凝胶局部敷料可替代一些患者的皮肤手术，用于自体或自体皮肤移植手术后（供区和受区）的创面。
同种异体创面敷料提供了一种有效的治疗方法，可更快地实现上皮化和伤口愈合，降低患者的瘢痕和炎症水平以及恢复时间，最终改善烧伤创面管理和提高烧伤治疗质量。
