伴有子宫内膜异位囊肿而切除的卵巢组织可能反映相邻卵巢的质量。

Ovarian Tissue Removed with Endometrioma May Reflect the Quality of the Adjacent Ovary.

作者信息

Martire Francesco G, Yacoub Veronica, Fuggetta Eliana, Carletti Valerio, Lazzeri Lucia, Centini Gabriele, D'Abate Claudia, Sorrenti Giuseppe, Zupi Errico, Maneschi Francesco

机构信息

Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena, 53100 Siena, Italy.

Department of Obstetrics and Gynecology, Tor Vergata University, 00133 Rome, Italy.

出版信息

Healthcare (Basel). 2025 Apr 20;13(8):948. doi: 10.3390/healthcare13080948.

DOI:10.3390/healthcare13080948

PMID:40281897

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12026716/

Abstract

: Endometriosis is commonly associated with infertility due to multiple factors. In this paper, we investigated the histopathological factors underlying these effects by comparing microscopic samples obtained during laparoscopic stripping. : Morpho-functional examination through the follicular Score (FS) of ovarian tissue adjacent to the cystic wall (Specimen 1) was compared with the FS of ovarian tissue inadvertently harvested during cystectomy (Specimen 2). The follicular score was compared with clinical factors such as age, parity, BMI, and CA-125 levels. : Cohen's kappa analysis revealed a 77.8% concordance between the follicular score of the ovarian tissue alongside the endometrioma (S1) and the ovarian tissue inadvertently removed (S2), reflecting a moderate level of concordance between the two samples. A statistically significant positive correlation was observed between the FS of Specimen 1 and the preoperative CA-125 value ( = 0.01); in contrast, a negative correlation was found between the FS and both the patient's age ( = 0.006) and parity ( = 0.03). Additionally, a statistically significant negative correlation was demonstrated between the FS of Specimen 2 and patient age ( = 0.04). : The functional quality of the remaining ovary after endometrioma stripping may be assessed by evaluating the follicular score of the pericystic ovarian tissue.

摘要

子宫内膜异位症通常因多种因素与不孕相关。在本文中，我们通过比较腹腔镜剥离过程中获取的显微样本，研究了这些影响背后的组织病理学因素。：通过对囊肿壁相邻卵巢组织（样本1）的卵泡评分（FS）进行形态功能检查，并与囊肿切除术中意外获取的卵巢组织（样本2）的FS进行比较。将卵泡评分与年龄、产次、体重指数和CA - 125水平等临床因素进行比较。：科恩kappa分析显示，子宫内膜瘤旁卵巢组织（S1）的卵泡评分与意外切除的卵巢组织（S2）之间的一致性为77.8%，反映出两个样本之间的一致性处于中等水平。样本1的FS与术前CA - 125值之间存在统计学显著正相关（= 0.01）；相反，FS与患者年龄（= 0.006）和产次（= 0.03）均呈负相关。此外，样本2的FS与患者年龄之间存在统计学显著负相关（= 0.04）。：子宫内膜瘤剥离后剩余卵巢的功能质量可通过评估囊肿周围卵巢组织的卵泡评分来评估。