Wang Peng, Hu Xin, Shan Xiang'ao, Gao Jiarui, Guo Fei, Wang Bingyuan, Liu Guoshi
Beijing Key Laboratory for Animal Genetic Improvement, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Beijing Changping District Animal Disease Prevention and Control Centre, Beijing 102200, China.
Animals (Basel). 2025 Apr 11;15(8):1110. doi: 10.3390/ani15081110.
In dairy cow, the peripartum metabolic stage is critical as may affect post-partum metabolic and reproductive recovery, colostrum quality, and overall reproductive fitness. This study aimed to evaluate the effects of varying doses of α-ketoglutarate (AKG) on lactation performance, reproductive performance, immune function, and antioxidant capacity in periparturient dairy cows. A total of 180 periparturient dairy cows were randomly assigned to four groups, with each cow receiving 1 g, 5 g, or 10 g of AKG in their prepartum diets. Results indicated that feeding 5 g and 10 g of AKG significantly increased the colostrum fat and protein content, reduced somatic cell counts, and improved daily milk yield. Regarding reproduction, AKG supplementation regulated reproductive hormones, increased postpartum estrogen levels, improved conception rates, and shortened the interval between breeding periods. For immune and antioxidant functions, AKG significantly increased serum IL-10 levels while reducing TNF-α and interleukins 1β and 6. It also significantly elevated glutathione peroxidase (GSH-PX) levels, reducing oxidative stress and demonstrating anti-inflammatory and immunomodulatory effects. Additionally, cows receiving medium-to-high doses of AKG had a significantly lower incidence of postpartum diseases such as mastitis. In conclusion, appropriate AKG supplementation can improve lactation performance, reproductive performance, immune function, and overall health in periparturient dairy cows, providing a theoretical basis for its use in dairy cow nutrition management.
在奶牛中，围产期代谢阶段至关重要，因为它可能会影响产后的代谢和生殖恢复、初乳质量以及整体繁殖健康状况。本研究旨在评估不同剂量的α-酮戊二酸（AKG）对围产期奶牛泌乳性能、繁殖性能、免疫功能和抗氧化能力的影响。总共180头围产期奶牛被随机分为四组，每头奶牛在产前日粮中分别添加1克、5克或10克AKG。结果表明，饲喂5克和10克AKG可显著提高初乳中的脂肪和蛋白质含量，降低体细胞计数，并提高日产奶量。在繁殖方面，补充AKG可调节生殖激素，提高产后雌激素水平，提高受孕率，并缩短配种间隔时间。对于免疫和抗氧化功能，AKG可显著提高血清白细胞介素-10（IL-10）水平，同时降低肿瘤坏死因子-α（TNF-α）以及白细胞介素1β和6的水平。它还能显著提高谷胱甘肽过氧化物酶（GSH-PX）水平，减轻氧化应激，具有抗炎和免疫调节作用。此外，接受中高剂量AKG的奶牛患乳腺炎等产后疾病的发生率显著较低。总之，适当补充AKG可改善围产期奶牛的泌乳性能、繁殖性能、免疫功能和整体健康状况，为其在奶牛营养管理中的应用提供了理论依据。
