Wachter Emily, Fox Levi H, Lu Zhixin, Jones Angelle D, Casto Nicholas D, Waltz Susan E
Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0521, USA.
Research Service, Cincinnati Veterans Affairs Hospital Medical Center, Cincinnati, OH 45220, USA.
Genes (Basel). 2025 Apr 6;16(4):437. doi: 10.3390/genes16040437.
The immune microenvironment plays a critical role in tumor growth and development. Immune activation within the tumor microenvironment is dynamic and can be modulated by tumor intrinsic and extrinsic signaling. The RON receptor tyrosine kinase is canonically associated with growth signaling and wound healing, and this receptor is frequently overexpressed in a variety of cancers. Epithelial cells, macrophages, dendritic cells, and fibroblasts express RON, presenting an important axis by which RON overexpressing tumors influence the tumor microenvironment. This review synthesizes the existing literature on the roles of tumor cell-intrinsic and -extrinsic RON signaling, highlighting areas of interest and gaps in knowledge that show potential for future studies.
免疫微环境在肿瘤生长和发展中起着关键作用。肿瘤微环境中的免疫激活是动态的，可受肿瘤内在和外在信号调节。RON受体酪氨酸激酶通常与生长信号和伤口愈合相关，该受体在多种癌症中经常过度表达。上皮细胞、巨噬细胞、树突状细胞和成纤维细胞表达RON，这是RON过表达肿瘤影响肿瘤微环境的一个重要轴。本综述综合了关于肿瘤细胞内在和外在RON信号作用的现有文献，突出了有研究价值的领域以及知识空白，这些领域显示出未来研究的潜力。
