Palacio Giraldo Adriana, Dammerer Verena, Neugebauer Johannes, Leone Gianpaolo, Schindler Melanie, Dammerer Dietmar
Department of Orthopedics and Traumatology, Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria.
Division of Orthopedics and Traumatology, University Hospital Krems, Mitterweg 10, 3500 Krems, Austria.
Cancers (Basel). 2025 Apr 11;17(8):1296. doi: 10.3390/cancers17081296.
The advent of novel cancer therapies has significantly improved both life expectancy and quality of life for cancer patients. However, this has also led to an increased incidence of metastases, particularly spinal metastases, which pose a significant clinical challenge due to their potential to compromise spinal stability, mobility and neurological function.
The aim of this study is to identify current symptom scores, determine the diagnosis, evaluate treatment modalities, and review prognostic scores and management algorithms for spinal metastases to aid in therapeutic decision making.
A systematic literature review was conducted in PubMed focusing on available full-text review articles published in English between 1 January 2012 and 1 July 2022. The search terms were "spinal metastasis OR spinal metastases OR spine metastasis OR spine metastases AND treatment OR management".
Several treatment algorithms, including NOMS (neurology, oncology, mechanical stability, and systemic disease) and LMNOP (localization, mechanical instability, neurology, oncology), have been proposed to guide clinical decision making. However, the development of prognostic scores that incorporate the impact of newer treatment modalities remains an important area of research.
Effective management of spinal metastases requires a multidisciplinary approach, with emphasis on early diagnosis. Treatment decisions are individualized. Further research is essential to refine treatment strategies and improve patient outcomes.
新型癌症疗法的出现显著提高了癌症患者的预期寿命和生活质量。然而，这也导致转移瘤的发生率增加，尤其是脊柱转移瘤，因其可能损害脊柱稳定性、活动能力和神经功能，从而带来重大临床挑战。
本研究旨在确定当前的症状评分、明确诊断、评估治疗方式，并回顾脊柱转移瘤的预后评分和管理算法，以辅助治疗决策。
在PubMed上进行了系统的文献综述，重点关注2012年1月1日至2022年7月1日期间发表的英文全文综述文章。检索词为“脊柱转移瘤或脊柱转移或脊椎转移瘤或脊椎转移以及治疗或管理”。
已经提出了几种治疗算法，包括NOMS（神经学、肿瘤学、机械稳定性和全身疾病）和LMNOP（定位、机械不稳定、神经学、肿瘤学），以指导临床决策。然而，纳入更新治疗方式影响的预后评分的开发仍然是一个重要的研究领域。
脊柱转移瘤的有效管理需要多学科方法，重点是早期诊断。治疗决策是个体化的。进一步的研究对于完善治疗策略和改善患者预后至关重要。
