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微血管减压手术中预防脑脊液漏的硬脑膜闭合策略

Dura Closure Tactics to Prevent CSF Leakage in Microvascular Decompression Surgery.

作者信息

Lee Hyun Seok, Park Kwan

机构信息

Department of Neurosurgery, Konkuk University Medical Center, Seoul 05030, Republic of Korea.

出版信息

Life (Basel). 2025 Apr 1;15(4):574. doi: 10.3390/life15040574.

DOI:10.3390/life15040574
PMID:40283128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12028582/
Abstract

(1) Background: Achieving a complete and secure dural closure to prevent cerebrospinal fluid (CSF) leakage is a critical concern in microvascular decompression (MVD). Proper dural closure minimizes complications, such as infections caused by CSF leakage. This study introduces a novel three-step dural suturing method, termed the "triple-layer closing technique". (2) Methods: From September 2020 to March 2023, a total of 475 patients underwent MVD surgery at our institution, all of whom received dural closure using the triple-layer closing technique. This technique incorporates three layers: Duragen (synthetic dura, Integra Lifesciences), TachoSil (collagen matrix, Nycomed), and polymethyl methacrylate (PMMC) bone cement. Postoperative complications, including CSF leakage and infections, were retrospectively analyzed. (3) Results: CSF leakage was observed in five patients (1.1%), all of whom presented with CSF rhinorrhea and radiological evidence of effusion within the mastoid air cells. These patients were successfully treated with lumbar drainage, and none required reoperation. No other postoperative infections or complications were reported. (4) Conclusions: The triple-layer closing technique, utilizing Duragen, TachoSil, and PMMC bone cement, is an effective and reliable method for dural closure. This technique significantly reduces the risk of CSF leakage and surgical site infections, enhancing postoperative outcomes in MVD procedures.

摘要

(1)背景:实现完整且安全的硬脑膜闭合以防止脑脊液(CSF)漏出是微血管减压术(MVD)中的关键问题。恰当的硬脑膜闭合可将并发症(如脑脊液漏引起的感染)降至最低。本研究介绍了一种新颖的三步硬脑膜缝合方法,称为“三层闭合技术”。(2)方法:从2020年9月至2023年3月,共有475例患者在本机构接受了MVD手术,所有患者均采用三层闭合技术进行硬脑膜闭合。该技术包含三层:Duragen(合成硬脑膜,英特格拉生命科学公司)、TachoSil(胶原基质,耐科明公司)和聚甲基丙烯酸甲酯(PMMC)骨水泥。对术后并发症,包括脑脊液漏和感染进行了回顾性分析。(3)结果:5例患者(1.1%)出现脑脊液漏,所有患者均表现为脑脊液鼻漏以及乳突气房内积液的影像学证据。这些患者通过腰椎引流成功治愈,无一例需要再次手术。未报告其他术后感染或并发症。(4)结论:利用Duragen、TachoSil和PMMC骨水泥的三层闭合技术是一种有效且可靠的硬脑膜闭合方法。该技术显著降低了脑脊液漏和手术部位感染的风险,改善了MVD手术的术后效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1771/12028582/107424ccc0a4/life-15-00574-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1771/12028582/79758dcfa44f/life-15-00574-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1771/12028582/dc61a343b7b4/life-15-00574-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1771/12028582/ca55b49dbc24/life-15-00574-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1771/12028582/107424ccc0a4/life-15-00574-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1771/12028582/79758dcfa44f/life-15-00574-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1771/12028582/dc61a343b7b4/life-15-00574-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1771/12028582/ca55b49dbc24/life-15-00574-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1771/12028582/107424ccc0a4/life-15-00574-g004.jpg

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引用本文的文献

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Reply to Saher, L. Outcomes of Microvascular Decompression Surgery: A Study on Cerebrospinal Fluid Leakage and Surgical Techniques. Comment on "Lee, H.S.; Park, K. Dura Closure Tactics to Prevent CSF Leakage in Microvascular Decompression Surgery. 2025, , 574".对萨赫尔的回复,L. 微血管减压手术的结果:一项关于脑脊液漏和手术技术的研究。对“李,H.S.;朴,K. 微血管减压手术中预防脑脊液漏的硬脑膜关闭策略。2025年,,574”的评论。
Life (Basel). 2025 Jul 1;15(7):1056. doi: 10.3390/life15071056.
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Outcomes of Microvascular Decompression Surgery: A Study on Cerebrospinal Fluid Leakage and Surgical Techniques. Comment on Lee, H.S.; Park, K. Dura Closure Tactics to Prevent CSF Leakage in Microvascular Decompression Surgery. 2025, , 574.微血管减压手术的结果:关于脑脊液漏和手术技术的研究。对李,H.S.;朴,K.《微血管减压手术中预防脑脊液漏的硬脑膜闭合策略》的评论。2025年,,574。
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