Hoornenborg C Warner, Somogyi Edit, Bruggink Jan E, Boyle Christina N, Lutz Thomas A, Emous Marloes, van Beek André P, van Dijk Gertjan
Department of Behavioral Neuroscience, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, 9747 AG Groningen, The Netherlands.
Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
J Clin Med. 2025 Apr 11;14(8):2642. doi: 10.3390/jcm14082642.
: Roux-en-Y gastric bypass (RYGB) surgery results in weight reduction and decreased energy intake and can ameliorate type 2 diabetes. These beneficial effects are usually attributed to changes in hunger and satiety and relatively rapid improvements in glycemic control, but these effects may depend on dietary adherence. The aim of this study is to investigate the relatively early effects of RYGB surgery on weight reduction (by focusing on eating patterns) and glycemic control in rats subjected to a healthy maintenance diet or an unhealthy Western-style diet. Rats were fed a high-fat diet with added sucrose (HF/S) or a low-fat (LF) diet. Body weight, high-resolution tracking of meal-related parameters, and glucose regulation after overnight fasting and during a mixed meal tolerance test (MMTT; 2 mL sweet/condensed milk) were measured before and after RYGB (RYGB+) or sham surgery (RYGB-). HF/S feeding led to an increased body weight just before RYGB surgery, but it also caused enhanced weight loss following RYGB, which led to similar body weights in the HF/S and LF diet groups twenty-four days post-operatively. RYGB surgery and diet dependently and independently influenced meal-related parameter outcomes, where both RYGB+ and HF/S feeding resulted in shorter meal duration ( < 0.01), higher ingestion rates ( < 0.001), and increased satiety ratio ( < 0.05), especially in the HF/S diet group subjected to RYGB. While RYGB surgery generally improved baseline glycemic parameters including HOMA-IR ( < 0.01), it often interacted with diet to affect MMTT-induced hyperglycemia ( < 0.05), beta-cell sensitivity ( < 0.01), and the insulinogenic index ( < 0.01), with the LF rats overall maintaining better glycemic control than the HF/S-fed rats. This study shows the importance of controlling diet after RYGB surgery, as diet type significantly influences ingestive behavior, post-prandial glucose regulation, beta-cell sensitivity, and glucose tolerance after RYGB.
Roux-en-Y胃旁路术（RYGB）手术可导致体重减轻和能量摄入减少，并能改善2型糖尿病。这些有益效果通常归因于饥饿感和饱腹感的变化以及血糖控制的相对快速改善，但这些效果可能取决于饮食依从性。本研究的目的是调查RYGB手术对接受健康维持饮食或不健康西式饮食的大鼠体重减轻（通过关注饮食模式）和血糖控制的相对早期影响。大鼠被喂食添加蔗糖的高脂肪饮食（HF/S）或低脂肪（LF）饮食。在RYGB手术（RYGB+）或假手术（RYGB-）前后，测量体重、与进餐相关参数的高分辨率跟踪，以及过夜禁食后和混合餐耐量试验（MMTT；2 mL甜/炼乳）期间的血糖调节。在RYGB手术前，HF/S喂养导致体重增加，但它也导致RYGB后体重减轻增强，这导致术后24天HF/S和LF饮食组的体重相似。RYGB手术和饮食分别独立地影响与进餐相关的参数结果，其中RYGB+和HF/S喂养均导致进餐持续时间缩短（<0.01）、摄入率更高（<0.001）和饱腹感比率增加（<0.05），尤其是在接受RYGB的HF/S饮食组中。虽然RYGB手术总体上改善了包括HOMA-IR在内的基线血糖参数（<0.01），但它经常与饮食相互作用，影响MMTT诱导的高血糖（<0.05）、β细胞敏感性（<0.01）和胰岛素生成指数（<0.01），总体而言，LF大鼠的血糖控制比HF/S喂养的大鼠更好。这项研究表明了RYGB手术后控制饮食的重要性，因为饮食类型显著影响RYGB后的摄食行为、餐后血糖调节、β细胞敏感性和葡萄糖耐量。
