Moreal Chiara, Martini Luca, Prataviera Francesca, Tascini Carlo, Giuliano Simone
Department of Medicine, University of Udine, 33100 Udine, Italy.
Clinical of Infectious Disease, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy.
J Clin Med. 2025 Apr 15;14(8):2722. doi: 10.3390/jcm14082722.
: Elastomeric infusion pumps have emerged as a transformative tool in outpatient parenteral antimicrobial therapy (OPAT), enabling continuous intravenous administration outside hospital settings, enhancing patient autonomy, reducing healthcare costs, and playing a role in antimicrobial stewardship. This aim of this review is to update current evidence on antibiotic stability in elastomeric infusion pumps, analyzing environmental factors, clinical efficacy, and practical challenges associated with OPAT implementation. : A narrative review was conducted using PubMed and the Cochrane Library, focusing on studies published between 2022 and 2025. Included studies assessed antibiotic stability in elastomeric pumps under real-world and laboratory conditions, examining factors such as temperature sensitivity, light exposure, and material interactions. : Findings indicate considerable variability in antibiotic stability, with some agents maintaining prolonged efficacy while others degrade rapidly under certain conditions. Antibiotics with greater stability are better suited for OPAT, whereas those prone to degradation present challenges for continuous infusion. Clinical studies report favorable treatment outcomes, including high cure rates and manageable adverse event profiles. However, discrepancies between laboratory-controlled conditions and real-world settings highlight the necessity for more comprehensive stability evaluations to ensure optimal antibiotic selection and administration in OPAT programs. : Optimizing antibiotic formulations, standardizing stability protocols, and advancing elastomeric pump technologies are essential for enhancing OPAT effectiveness. Future research should focus on real-world simulation studies and refining device materials to expand the range of stable antibiotics, ensuring safer and more efficient outpatient antimicrobial therapy.
弹性体输液泵已成为门诊胃肠外抗菌治疗（OPAT）中的一种变革性工具，能够在医院外进行持续静脉给药，增强患者自主性，降低医疗成本，并在抗菌药物管理中发挥作用。本综述的目的是更新关于弹性体输液泵中抗生素稳定性的现有证据，分析与OPAT实施相关的环境因素、临床疗效和实际挑战。：使用PubMed和Cochrane图书馆进行了叙述性综述，重点关注2022年至2025年发表的研究。纳入的研究评估了弹性体泵在实际和实验室条件下的抗生素稳定性，研究了温度敏感性、光照和材料相互作用等因素。：研究结果表明抗生素稳定性存在很大差异，一些药物在某些条件下能保持较长时间的疗效，而另一些则会迅速降解。稳定性较高的抗生素更适合OPAT，而那些易于降解的抗生素在连续输注时存在挑战。临床研究报告了良好的治疗结果，包括高治愈率和可管理的不良事件情况。然而，实验室控制条件与实际环境之间的差异凸显了进行更全面稳定性评估的必要性，以确保在OPAT项目中选择和使用最佳抗生素。：优化抗生素配方、规范稳定性方案以及推进弹性体泵技术对于提高OPAT有效性至关重要。未来的研究应侧重于实际模拟研究和改进设备材料，以扩大稳定抗生素的范围，确保更安全、更有效的门诊抗菌治疗。
