Fonton Pérince, Grant Rebecca, Gasser Michael, Buetti Niccolò, Kronenberg Andreas, Harbarth Stephan
Infection Control Program, Geneva University Hospitals and Faculty of Medicine, WHO Collaborating Center, Rue Gabrielle-Perret-Gentil 4, CH-1205 Geneva, Switzerland.
Swiss Centre for Antibiotic Resistance (ANRESIS), Institute for Infectious Diseases, University of Bern, 3001 Bern, Switzerland.
Microorganisms. 2025 Mar 29;13(4):786. doi: 10.3390/microorganisms13040786.
We conducted a retrospective analysis of spp. surveillance data from acute care hospitals that contributed spp. data to the national surveillance system ANRESIS from January 2010 to December 2022. The incidence of spp. bloodstream infections (BSIs) in Switzerland was calculated, as well as the proportion of spp. isolates from urinary tract samples. We also evaluated the susceptibility of spp. isolates to clinically important antibiotics. From 2010 to 2022, there were 33,958 spp. from patients across 55 acute care hospitals continuously participating in ANRESIS included in this analysis. We observed an annual increase in the number of spp. BSIs, from 2.5 to 4.2 cases per 100,000 patient days (IRR: 1.04, 95% CI: 0.96-1.12). We found a higher incidence among male versus female patients (IRR: 2.47, 95% CI: 1.28-4.74) and in those aged ≥65 years, as compared with younger patients (IRR: 2.26, 95% CI: 1.18-4.32). The proportion of spp. among positive urinary tract samples also increased (from 18.6 to 24.7 per 1000 samples). Among ICU patients, there was a considerable proportion of resistance to third-generation cephalosporins among isolates (26.8-44.0%), compared with non- isolates (1.7-6.9%). spp. is gaining clinical importance in Switzerland; further studies are needed to better understand the underlying mechanisms.
我们对2010年1月至2022年12月期间向国家监测系统ANRESIS提供数据的急性护理医院的 spp. 监测数据进行了回顾性分析。计算了瑞士 spp. 血流感染（BSIs）的发病率以及尿路样本中 spp. 分离株的比例。我们还评估了 spp. 分离株对临床重要抗生素的敏感性。2010年至2022年期间，本分析纳入了来自55家持续参与ANRESIS的急性护理医院患者的33958株 spp.。我们观察到 spp. BSIs的数量逐年增加，从每10万患者日2.5例增至4.2例（发病率比值比：1.04，95%置信区间：0.96 - 1.12）。我们发现男性患者的发病率高于女性患者（发病率比值比：2.47，95%置信区间：1.28 - 4.74），并且≥65岁患者的发病率高于年轻患者（发病率比值比：2.26，95%置信区间：1.18 - 4.32）。阳性尿路样本中 spp. 的比例也有所增加（从每1000份样本中的18.6例增至24.7例）。在重症监护病房（ICU）患者中， 分离株对第三代头孢菌素的耐药比例相当高（26.8% - 44.0%），而非 分离株的耐药比例为（1.7% - 6.9%）。 spp. 在瑞士正变得具有临床重要性；需要进一步研究以更好地了解其潜在机制。
