Kostare Georgia, Kostares Evangelos, Kostares Michael, Halkitis Perry N, Tsakris Athanasios, Xanthos Theodoros, Kantzanou Maria
Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece.
Department of Anatomy, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece.
Viruses. 2025 Apr 5;17(4):531. doi: 10.3390/v17040531.
Human herpesvirus 6 (HHV-6) is a ubiquitous virus with significant implications for immunocompromised individuals, particularly people living with HIV (PLWH). This study aimed to estimate the prevalence of HHV-6 detection in blood samples among PLWH using molecular diagnostic techniques. A systematic literature search was conducted across multiple databases until September 2024, including studies that reported HHV-6 detection in blood samples of PLWH through molecular methods. The meta-analysis calculated pooled prevalence rates using a random-effects model and assessed study quality, with additional analyses for outlier identification and influential study effects. Twelve studies met the inclusion criteria, and the random-effects model estimated the prevalence of HHV-6 detection at 11.7% (95% CI: 4.3-21.8%), with considerable heterogeneity. Influence diagnostics identified one study as influential, and after its exclusion, the recalculated pooled prevalence was 8% (95% CI: 4.4-12.4%), with reduced but still considerable heterogeneity. This meta-analysis highlights the prevalence of HHV-6 detection in PLWH, emphasizing the need for ongoing research to explore the clinical implications and factors influencing viral detection as well as the implications of this coinfection on the treatment and overall health of PLWH.
人疱疹病毒6型（HHV-6）是一种普遍存在的病毒，对免疫功能低下的个体，尤其是艾滋病毒感染者（PLWH）具有重大影响。本研究旨在使用分子诊断技术估计PLWH血液样本中HHV-6检测的患病率。在多个数据库中进行了系统的文献检索，直至2024年9月，包括通过分子方法报告PLWH血液样本中HHV-6检测的研究。荟萃分析使用随机效应模型计算合并患病率，并评估研究质量，还进行了异常值识别和有影响研究效应的额外分析。12项研究符合纳入标准，随机效应模型估计HHV-6检测的患病率为11.7%（95%CI：4.3-21.8%），存在相当大的异质性。影响诊断确定一项研究有影响，排除该研究后，重新计算的合并患病率为8%（95%CI：4.4-12.4%），异质性有所降低但仍然相当大。这项荟萃分析突出了PLWH中HHV-6检测的患病率，强调需要持续开展研究，以探索临床意义、影响病毒检测的因素以及这种合并感染对PLWH治疗和整体健康的影响。
