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海藻搁浅物中的硫酸多糖作为抗病毒 1 的潜在抗病毒药物的可再生资源。

Sulfated Polysaccharides from Seaweed Strandings as Renewable Source for Potential Antivirals against Virus 1.

机构信息

Laboratoire de Biotechnologie et Chimie Marines, Université Bretagne Sud, EA3884, IUEM, 56000 Vannes, France.

Plateforme RMN-RPE, Service Général des Plateformes, UFR Sciences et Techniques, Université Bretagne Occidentale, 6 Av. V. Le Gorgeu CS93837, CEDEX 3, 29238 Brest, France.

出版信息

Mar Drugs. 2022 Feb 1;20(2):116. doi: 10.3390/md20020116.

DOI:10.3390/md20020116
PMID:35200645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8878361/
Abstract

virus 1 (HSV-1) remains a prominent health concern widespread all over the world. The increasing genital infections by HSV-1 that might facilitate acquisition and transmission of HIV-1, the cumulative evidence that HSV-1 promotes neurodegenerative disorders, and the emergence of drug resistance signify the need for new antiviral agents. In this study, the in vitro anti-herpetic activity of sulfated polysaccharides (SPs) extracted by enzyme or hot water from seaweeds collected in France and Mexico from stranding events, were evaluated. The anti-herpetic activity evaluation of the semi-refined-polysaccharides (sr-SPs) and different ion exchange purified fractions showed a wide range of antiviral activity. Among them, the sr-SPs from the Rhodophyta showed stronger activity EC 0.68 μg/mL with SI 1470, without cytotoxicity. Further, the antiviral activity of the sr-SPs evaluated at different treatment schemes showed a high EC of 0.38 μg/mL during the viral adsorption assays when the polysaccharide and the virus were added simultaneously, whilst the protection on Vero cell during the post-infection assay was effective up to 1 h. The chemical composition, FTIR and H NMR spectroscopic, and molecular weights of the sr-SPs from were determined and discussed based on the anti-herpetic activity. The potential utilization of seaweed stranding as a source of antiviral compounds is addressed.

摘要

病毒 1（HSV-1）仍然是一个普遍存在的全球健康关注点。HSV-1 引起的生殖器感染不断增加，可能会促进 HIV-1 的获得和传播，越来越多的证据表明 HSV-1 会促进神经退行性疾病，以及耐药性的出现，这些都表明需要新的抗病毒药物。在这项研究中，评估了从法国和墨西哥搁浅事件中采集的海藻，通过酶或热水提取的硫酸化多糖（SPs）的体外抗疱疹活性。对半精制多糖（sr-SPs）和不同离子交换纯化部分的抗疱疹活性评估显示出广泛的抗病毒活性。其中，红藻中的 sr-SPs 表现出更强的活性，EC0.68μg/mL，SI1470，无细胞毒性。此外，在不同治疗方案下评估 sr-SPs 的抗病毒活性表明，在病毒吸附试验中，当多糖和病毒同时添加时，其 EC 高达 0.38μg/mL，而在感染后试验中对 Vero 细胞的保护作用在 1 小时内有效。根据抗疱疹活性，确定并讨论了来自的 sr-SPs 的化学组成、FTIR 和 H NMR 光谱以及分子量。探讨了海藻搁浅作为抗病毒化合物来源的潜在利用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/648c5db7fe84/marinedrugs-20-00116-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/e41e6ee8d3d0/marinedrugs-20-00116-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/4e96d4b0f432/marinedrugs-20-00116-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/a132d51d9cc8/marinedrugs-20-00116-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/c6f5e9c99fa2/marinedrugs-20-00116-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/39b0c0f9d02c/marinedrugs-20-00116-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/648c5db7fe84/marinedrugs-20-00116-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/e41e6ee8d3d0/marinedrugs-20-00116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/2a6048a19a6e/marinedrugs-20-00116-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/12c2da2c702c/marinedrugs-20-00116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/4e96d4b0f432/marinedrugs-20-00116-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/a132d51d9cc8/marinedrugs-20-00116-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/c6f5e9c99fa2/marinedrugs-20-00116-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/39b0c0f9d02c/marinedrugs-20-00116-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea6d/8878361/648c5db7fe84/marinedrugs-20-00116-g008.jpg

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