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撤稿声明:聚乙二醇2000-二棕榈酰磷脂酰乙醇胺包被的槲皮素纳米颗粒通过诱导C6胶质瘤细胞程序性死亡显著增强抗癌效果。

RETRACTION: PEG2000-DPSE-Coated Quercetin Nanoparticles Remarkably Enhanced Anticancer Effects through Induced Programed Cell Death on C6 Glioma Cells.

出版信息

J Biomed Mater Res A. 2025 May;113(5):e37894. doi: 10.1002/jbm.a.37894.

DOI:10.1002/jbm.a.37894
PMID:40285751
Abstract

G. Wang, JJ. Wang, J. Luo, L. Wang, XL. Chen, LP. Zhang, and SQ. Jiang, "PEG2000-DPSE-Coated Quercetin Nanoparticles Remarkably Enhanced Anticancer Effects through Induced Programed Cell Death on C6 Glioma Cells," Journal of Biomedical Materials Research Part A 101, no. 11 (2013): 3076-3085, https://doi.org/10.1002/jbm.a.34607. The above article, published online on 25 March 2013, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, J. Kent Leach; and Wiley Periodicals LLC. A third party reported several concerns to the publisher about duplicated images in this article, including duplication of a plot between Figures 4B and 4D; duplication of an image within Figure 4E; and duplication of all images in Figure 4E with another article published by many of the same authors (Wang, et al. 2013 [https://doi.org/10.1038/cddis.2013.242]). Further investigation by the publisher uncovered evidence of duplication, manipulation, and resizing of western blot images between Figures 5D and 5E; duplication of beta-actin bands between Figures 5C, 5D, and 6E; and insertion of a band in Figure 6E. The authors responded to an inquiry by the publisher and stated that the image duplications were the result of errors during figure preparation and labeling the original data. However, the parties agree that the explanations and data supplied by the authors did not properly address the concerns raised. The retraction has been agreed to because the evidence of image duplication and manipulation fundamentally compromises the reliability of the data and conclusions reported in this article. The authors did not respond to our notice regarding the retraction.

摘要

王G、王JJ、罗J、王L、陈XL、张LP和姜SQ,“聚乙二醇2000 - 二硬脂酰磷脂酰乙醇胺包被的槲皮素纳米颗粒通过诱导C6胶质瘤细胞程序性细胞死亡显著增强抗癌效果”,《生物医学材料研究杂志A辑》101卷,第11期(2013年):3076 - 3085页,https://doi.org/10.1002/jbm.a.34607 。上述文章于2013年3月25日在线发表于威利在线图书馆(http://onlinelibrary.wiley.com/),已根据期刊主编J. 肯特·利奇与威利期刊有限责任公司的协议撤回。第三方就本文中的重复图像问题向出版商提出了若干担忧,包括图4B和4D之间一个图表的重复;图4E中一幅图像的重复;以及图4E中的所有图像与许多相同作者发表的另一篇文章(王等人,2013年[https://doi.org/10.1038/cddis.2013.242])中的重复。出版商的进一步调查发现了图5D和5E之间蛋白质免疫印迹图像存在重复、处理和调整大小的证据;图5C、5D和6E之间β - 肌动蛋白条带的重复;以及图6E中一条带的插入。作者对出版商的询问做出回应,并表示图像重复是图准备和标记原始数据过程中出现错误的结果。然而,各方一致认为作者提供的解释和数据未能妥善解决所提出的担忧。之所以同意撤回,是因为图像重复和处理的证据从根本上损害了本文所报告数据和结论的可靠性。作者未对我们关于撤回的通知做出回应。

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