Wang Rongrong, Zhang Zhili, Jiang Wei, Liu Junyi, Tian Chao, Wang Meng
College of Pharmacy, Beihua University, Jilin 132013, China.
Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Molecules. 2025 Mar 22;30(7):1421. doi: 10.3390/molecules30071421.
Neuroinflammation is considered a significant factor in triggering numerous neurodegenerative diseases. Hence, the development of effective anti-inflammatory drugs is of utmost urgency. In this study, three series of new isatin-chalcone hybrid derivatives were successfully designed and synthesized, and their anti-neuritis activities were explored using BV2 microglial cells. The results indicated that compound exhibited the most potent anti-inflammatory activity (IC = 1.6 μM; TI = 21.6). After being treated with compound , the production of TNF-α and IL-6 decreased significantly ( < 0.0001). molecular modeling studies on inflammation proteins suggested that compound might bind to TLR4/MD2 and p38. Predicted by the software Molinspiration, the Log value and Log BB of compound were 3.36 and -0.32, respectively.
神经炎症被认为是引发多种神经退行性疾病的一个重要因素。因此，开发有效的抗炎药物迫在眉睫。在本研究中，成功设计并合成了三个系列的新型异吲哚酮-查尔酮杂化衍生物，并利用BV2小胶质细胞探究了它们的抗神经炎活性。结果表明，化合物表现出最有效的抗炎活性（IC = 1.6 μM；TI = 21.6）。用化合物处理后，TNF-α和IL-6的产生显著降低（< 0.0001）。对炎症蛋白的分子模拟研究表明，化合物可能与TLR4/MD2和p38结合。通过软件Molinspiration预测，化合物的Log 值和Log BB分别为3.36和 -0.32。
