Reischer Theresa, Catic Anja, Brennus Charlotte, Göbl Christian, Yerlikaya-Schatten Gülen
Department of Obstetrics and Gynaecology, Division of Obstetrics and feto-maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, A-1090, Austria.
BMC Pregnancy Childbirth. 2025 Apr 26;25(1):508. doi: 10.1186/s12884-025-07611-2.
Provision and uptake of antenatal screening is nonuniform in Austria, as there is no national screening program. The aim of the study was to evaluate the influence of prenatal ultrasound screening methods on the time of diagnosis and therefore the rate of feticide in pregnancies with fetal malformations.
Retrospective data analysis of terminations of pregnancies (TOP) with and without feticide due to fetal structural anomalies at a single tertiary care referral center in Austria between 2007 and 2020.
Over the study period, the number of TOPs increased overall, and a nonsignificant rise in the rate of feticide was observed. Women who underwent TOP without feticide significantly more often had first trimester screening; in particular, 588 (86%) cases compared to 121 (57%) with feticide (p < 0.001). Furthermore, in the subgroup of cases diagnosed after 20 weeks of pregnancy (WoP), a significant association between cases without a mid-trimester anomaly scan and TOP with feticide was found. Gestational age at diagnosis was influenced by the type of malformation and therefore the affected organ system.
First trimester screening is critical in early fetal assessment and preventing unnecessary late terminations and feticide. Mid-trimester anomaly scan further increases the early detection of fetal malformations, especially those that become apparent later in pregnancy. Consequently, comprehensive counselling regarding the benefits of prenatal ultrasound screening should be provided to all pregnant women.
由于奥地利没有全国性的筛查项目，该国产前筛查的提供和接受情况并不统一。本研究的目的是评估产前超声筛查方法对诊断时间的影响，进而评估胎儿畸形妊娠中的杀胎率。
对2007年至2020年奥地利一家三级医疗转诊中心因胎儿结构异常进行的有或无杀胎行为的妊娠终止（TOP）进行回顾性数据分析。
在研究期间，TOP的数量总体上有所增加，杀胎率有不显著的上升。未进行杀胎的TOP女性更常进行孕早期筛查；特别是，588例（86%）未杀胎的病例与121例（57%）杀胎的病例相比（p < 0.001）。此外，在妊娠20周后（WoP）诊断的病例亚组中，发现未进行孕中期异常扫描的病例与杀胎的TOP之间存在显著关联。诊断时的孕周受畸形类型及因此受影响的器官系统的影响。
孕早期筛查对早期胎儿评估以及预防不必要的晚期终止妊娠和杀胎至关重要。孕中期异常扫描进一步提高了胎儿畸形的早期检测率，尤其是那些在妊娠后期才显现的畸形。因此，应向所有孕妇提供有关产前超声筛查益处的全面咨询。
