Chen Xiaolin, Xiao Zhuoni, Cai Yuli, Pan Yizhuo
Department of Endocrinology, Renmin Hospital of Wuhan University, Wuhan, China.
Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, China.
Gynecol Endocrinol. 2025 Dec;41(1):2497854. doi: 10.1080/09513590.2025.2497854. Epub 2025 Apr 27.
The aim of this analysis is to assess the effect of obesity on reproductive hormones in Chineses patients with polycystic ovarian syndrome (PCOS). Seven databases were searched. The Newcastle-Ottawa Scale (NOS) assessed the quality of included studies. A meta-analysis was performed using random-effects model. The means and standard deviations of the outcomes were synthesized as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs). A total of 23 studies involving 4554 patients with PCOS were included. No significant differences in follicle-stimulating hormone (FSH) ( = 0.51), estradiol (E2) ( = 0.48), and prolactin (PRL) ( = 0.46) levels were found between obese and nonobese PCOS patients. However, obese PCOS patients had significantly lower levels of luteinizing hormone (LH) ( < 0.00001), LH/FSH ( = 0.001), progesterone (P) ( = 0.009), and anti-mullerian hormone (AMH) ( = 0.001). Conversely, they exhibited significantly higher testosterone (T) ( = 0.001) levels. Obese PCOS patients exhibited lower levels of LH, LH/FSH, P, and AMH, but higher T levels compared to nonobese PCOS patients, and no significant difference were observed in FSH, E2, and PRL levels in PCOS patients with and without obesity.
本分析的目的是评估肥胖对中国多囊卵巢综合征（PCOS）患者生殖激素的影响。检索了七个数据库。采用纽卡斯尔-渥太华量表（NOS）评估纳入研究的质量。使用随机效应模型进行荟萃分析。将结果的均值和标准差合成为标准化均值差（SMD）及相应的95%置信区间（CI）。共纳入23项研究，涉及4554例PCOS患者。肥胖与非肥胖PCOS患者之间的促卵泡生成素（FSH）（=0.51）、雌二醇（E2）（=0.48）和催乳素（PRL）（=0.46）水平无显著差异。然而，肥胖PCOS患者的黄体生成素（LH）水平显著较低（<0.00001）、LH/FSH（=0.001）、孕酮（P）（=0.009）和抗苗勒管激素（AMH）（=0.001）。相反，他们的睾酮（T）水平显著较高（=0.001）。与非肥胖PCOS患者相比，肥胖PCOS患者的LH、LH/FSH、P和AMH水平较低，但T水平较高，且肥胖和非肥胖PCOS患者的FSH、E2和PRL水平未观察到显著差异。
