Timsit-Berthier M, de Thier D, Machowsky R, Mantanus H, Rousseau J C
Curr Med Res Opin. 1985;9(8):552-9. doi: 10.1185/03007998509109634.
In an electropharmacokinetic study, the effects of lormetazepam and flunitrazepam were compared by the means of a sleep EEG and waking EEG during the following daytime. At a 1-week interval, 6 normal subjects received at random either 2 mg lormetazepam or 2 mg flunitrazepam in a double-blind, crossover fashion. Sleep EEG was recorded throughout the night; 6-min EEG samples were recorded every hour during 10 hours on the following daytime for spectral analysis. Night sleep after flunitrazepam showed lower Stage IV sleep than after lormetazepam. During daytime, only flunitrazepam induced an increased percentage of beta 2 frequencies, which remained above baseline up to 10 hours after awakening, indicating a prolonged impregnation time. This study permitted comparison of the relative intensity and duration of these two benzodiazepines: lormetazepam appeared to be a short-acting hypnotic while flunitrazepam displayed longer modification of the brain electrical activity.
在一项电药代动力学研究中，通过睡眠脑电图和次日白天的清醒脑电图，比较了氯美扎酮和氟硝西泮的作用。以1周为间隔，6名正常受试者以双盲、交叉方式随机接受2mg氯美扎酮或2mg氟硝西泮。整夜记录睡眠脑电图；次日白天10小时内每小时记录6分钟脑电图样本用于频谱分析。氟硝西泮后的夜间睡眠显示比氯美扎酮后的IV期睡眠少。在白天，只有氟硝西泮引起β2频率百分比增加，在觉醒后长达10小时仍高于基线，表明浸染时间延长。这项研究使得能够比较这两种苯二氮䓬类药物的相对强度和持续时间：氯美扎酮似乎是一种短效催眠药，而氟硝西泮对脑电活动的改变持续时间更长。
