Cativiela-Campos Blanca, Ruiz-Sobremazas Diego, Rodulfo-Cárdenas Rocío, Barrasa Angel, Sánchez-Santed Fernando, Colomina Maria Teresa, Aschner Michael, López-Granero Caridad
Department of Psychology and Sociology, University of Zaragoza, 44003, Teruel, Spain.
Universitat Rovira i Virgili, Research Group in Neurobehavior and Health (NEUROLAB), Tarragona, Spain; Universitat Rovira i Virgili, Department of Psychology and Research Center for Behavior Assessment (CRAMC), Tarragona, Spain; Universitat Rovira i Virgili, Center of Environmental, Food and Toxicological Technology (TECNATOX), Reus, Spain.
Environ Pollut. 2025 Jun 15;375:126279. doi: 10.1016/j.envpol.2025.126279. Epub 2025 Apr 25.
Environmental pollution poses a significant risk to human health. Particulate matter (PM) found in polluted air is particularly of concern due to its ability to penetrate the blood-brain barrier (BBB) and impact the central nervous system (CNS), affecting sensory, cognitive, and emotional well-being. The aim of this review is to provide a comprehensive overview on the latest evidence regarding the association between PM exposure and behavioral outcomes in adult and older populations. Searches were conducted across PubMed, Web of Science, and Scopus up to August 2023, with articles selected and screened following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 27 articles meeting the criteria were included, and their risk of bias was evaluated using the Newcastle Ottawa Scale. The studies primarily focused on PM2.5 and PM10 in regions such as Europe, the USA, and Asia. While data on the impact of PM exposure on sensory variables were limited, suggesting an adverse effect, overall findings indicated a link between PM exposure and worsened cognitive function, increased risk of dementia, depressive symptoms, and anxiety. Some studies highlighted sex-dependent effects of PM exposure, with women experiencing a higher prevalence of adverse effects. This review underscores the importance of further research to understand the specific cognitive aspects affected by PM exposure, particularly in relation to dementia risk.
环境污染对人类健康构成重大风险。污染空气中发现的颗粒物（PM）尤其令人担忧，因为它能够穿透血脑屏障（BBB）并影响中枢神经系统（CNS），进而影响感觉、认知和情绪健康。本综述的目的是全面概述有关成年和老年人群中PM暴露与行为结果之间关联的最新证据。截至2023年8月，在PubMed、科学网和Scopus上进行了检索，并按照系统评价和Meta分析的首选报告项目（PRISMA）指南选择和筛选文章。总共纳入了27篇符合标准的文章，并使用纽卡斯尔渥太华量表评估了它们的偏倚风险。这些研究主要集中在欧洲、美国和亚洲等地区的PM2.5和PM10。虽然关于PM暴露对感觉变量影响的数据有限，表明存在不利影响，但总体研究结果表明PM暴露与认知功能恶化、痴呆风险增加、抑郁症状和焦虑之间存在联系。一些研究强调了PM暴露的性别差异影响，女性出现不良反应的患病率更高。本综述强调了进一步研究以了解受PM暴露影响的特定认知方面的重要性，特别是与痴呆风险相关的方面。
