Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Ann Glob Health. 2023 Jun 23;89(1):45. doi: 10.5334/aogh.3889. eCollection 2023.
There is very little epidemiological evidence on the effects of ambient air pollution on brain tumor risk. The purpose of this study was to determine the relationship between exposure to air pollution and the incidence of brain tumors.
A comprehensive literature search in five international databases, including PubMed/Medline, ProQuest, Scopus, Embase, and ISI/WOS on April 15, 2019, was conducted. The methodology of the present study was based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement. The Newcastle-Ottawa Quality Assessment Form was used to evaluate the quality of the selected papers.
Five studies that measured adult brain tumors as well as their long-term exposure to at least one of the pollutants criteria for air pollution, PM absorbance, and proximity to traffic (Trafnear) were reviewed. The results showed that the pooled relative risk (RR) for incidence of brain tumor and long term exposure to Trafnear, PM, PM absorbance, O and NOx were RR = 1.07, (95% CI 0.99-1.16), P = 0.079, for Trafnear; RR = 0.90, (95% CI 0.80-1.00), P = 0.064 for PM; RR = 1.63, (95% CI 1.04-2.55), P = 0.031 for PM absorbance; RR = 1.3, (95% CI 1.03-1.6), P = 0.023 for O; and RR = 1.16, (95% CI 0.93-1.45), P = 0.173 for NOx. Exposure to other air pollutants had no statistically significant association with brain tumor incidence.
The results showed that exposure to air pollutants, such as O and PM absorbance, had the highest correlation with brain tumor incidence. They also showed an absence of correlation between exposure to certain pollutants (SO, CO, NO, PM, PM) and brain tumor incidence.
关于环境空气污染对脑瘤风险的影响，目前仅有很少的流行病学证据。本研究的目的是确定暴露于空气污染与脑瘤发病率之间的关系。
于 2019 年 4 月 15 日在五个国际数据库（包括 PubMed/Medline、ProQuest、Scopus、Embase 和 ISI/WOS）中进行了全面的文献检索。本研究的方法基于 PRISMA（系统评价和荟萃分析的首选报告项目）声明。使用纽卡斯尔-渥太华质量评估表来评估所选论文的质量。
综述了五项研究，这些研究均测量了成人脑瘤以及其对至少一种空气污染物标准（PM 吸光度、交通接近度（Trafnear））的长期暴露情况。结果表明，脑瘤发病率与长期暴露于 Trafnear、PM、PM 吸光度、O 和 NOx 的合并相对风险（RR）分别为 RR = 1.07（95%CI 0.99-1.16），P = 0.079，对于 Trafnear；RR = 0.90（95%CI 0.80-1.00），P = 0.064，对于 PM；RR = 1.63（95%CI 1.04-2.55），P = 0.031，对于 PM 吸光度；RR = 1.3（95%CI 1.03-1.6），P = 0.023，对于 O；RR = 1.16（95%CI 0.93-1.45），P = 0.173，对于 NOx。暴露于其他空气污染物与脑瘤发病率无统计学显著相关性。
结果表明，暴露于空气污染物，如 O 和 PM 吸光度，与脑瘤发病率相关性最高。它们还表明，暴露于某些污染物（SO、CO、NO、PM、PM）与脑瘤发病率之间没有相关性。
