Akay A, Akdaş-Reis Y, Yilmaz-Ergani S, Hajiyeva K, Engin-Üstün Y
Department of Obstetrics and Gynecology, Yalova State Hospital, Yalova, Turkiye.
Department of Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Education and Research Hospital, Ankara, Turkiye.
Niger J Clin Pract. 2025 Apr 1;28(4):545-551. doi: 10.4103/njcp.njcp_530_24. Epub 2025 Apr 26.
The processes involved in inflammatory regulation are crucial during pregnancy.
This study aims to identify the association between fetal growth restriction (FGR) and neutrophil-to-lymphocyte ratio (NLR), systemic inflammatory response index (SIRI), Systemic immune-inflammatory index (SII), and pan-immune inflammatory value (PIV).
This retrospective case-control study was conducted between 2015 and 2021. The study group comprised cases diagnosed with FGR, while the control group was randomly selected from a healthy cohort of pregnancies. The levels of inflammatory markers were calculated from the blood count results of the cases. A comparison was conducted between the two groups' obstetric and neonatal outcomes and serum inflammatory markers.
A total of 1052 cases were included in the study, with 526 (50%) belonging to the FGR group. The mean age was found to be similar in both groups (P = .311). A significant increase in neutrophils, NLR, SIRI, SII, and PIV was observed in the FGR group (P < .05). The multivariate logistic regression analysis results demonstrated that elevated neutrophil, NLR, and SII values were independent risk factors for FGR (P < .001). No notable discrepancy was observed in these markers between the early and late FGR (P > .05). A significant inverse relationship was observed between neutrophils, NLR, and SII, and gestational age and fetal weight at birth (P < .05).
The findings indicated that elevations in neutrophils, NLR, and SII are independent risk factors for FGR. These markers reflecting maternal systemic inflammation, have been linked to FGR and associated poor neonatal outcomes.
炎症调节过程在孕期至关重要。
本研究旨在确定胎儿生长受限（FGR）与中性粒细胞与淋巴细胞比值（NLR）、全身炎症反应指数（SIRI）、全身免疫炎症指数（SII）及全免疫炎症值（PIV）之间的关联。
本回顾性病例对照研究于2015年至2021年进行。研究组包括诊断为FGR的病例，对照组从健康妊娠队列中随机选取。根据病例的血常规结果计算炎症标志物水平。对两组的产科和新生儿结局以及血清炎症标志物进行比较。
本研究共纳入1052例病例，其中526例（50%）属于FGR组。发现两组的平均年龄相似（P = 0.311）。FGR组中性粒细胞、NLR、SIRI、SII和PIV显著升高（P < 0.05）。多因素逻辑回归分析结果表明，中性粒细胞、NLR和SII值升高是FGR的独立危险因素（P < 0.001）。早期和晚期FGR在这些标志物上未观察到明显差异（P > 0.05）。中性粒细胞、NLR和SII与孕周及出生时胎儿体重之间存在显著负相关（P < 0.05）。
研究结果表明，中性粒细胞、NLR和SII升高是FGR的独立危险因素。这些反映母体全身炎症的标志物与FGR及不良新生儿结局相关。
