Moscatelli Antonio A M, Ramirez Paloma L, Suprasert Bow, Tate Moranda, Cohen Stephanie E, Veras Maria Amelia S M, Baguso Glenda, Wilson Erin C, McFarland Willi
Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brazil.
San Francisco Department of Public Health, 25 Van Ness Avenue, Suite 710, San Francisco, CA, USA.
AIDS Behav. 2025 Apr 28. doi: 10.1007/s10461-025-04728-5.
In October 2022, the San Francisco Department of Public Health published guidelines for doxycycline post-exposure prophylaxis (doxy-PEP) to prevent bacterial sexually transmitted infections (STI) among men who have sex with men (MSM). We evaluated awareness and use of doxy-PEP using data from the National HIV Behavioral Surveillance in 2023 in San Francisco (N = 533). In the year following the publication of the guidelines, 66.6% of MSM reported awareness of doxy-PEP, and 19.3% had used it. Among MSM who are not living with HIV, awareness of doxy-PEP was associated with higher educational levels, condomless sex, bacterial STI diagnoses, and PrEP use; use was associated with STI diagnoses and PrEP use. Among MSM living with HIV, both awareness and use were associated with younger age. These findings indicate rapid dissemination and early adoption of doxy-PEP in a priority population in a real-world setting.
2022年10月，旧金山市公共卫生部发布了多西环素暴露后预防（多西环素-PEP）指南，以预防男男性行为者（MSM）中的细菌性性传播感染（STI）。我们使用2023年旧金山全国艾滋病行为监测数据（N = 533）评估了多西环素-PEP的知晓率和使用率。在指南发布后的一年里，66.6%的男男性行为者报告知晓多西环素-PEP，19.3%的人使用过。在未感染艾滋病毒的男男性行为者中，多西环素-PEP的知晓率与较高的教育水平、无保护性行为、细菌性性传播感染诊断以及暴露前预防（PrEP）的使用有关；使用率与性传播感染诊断和暴露前预防的使用有关。在感染艾滋病毒的男男性行为者中，知晓率和使用率均与较年轻的年龄有关。这些发现表明，在现实环境中，多西环素-PEP在优先人群中迅速传播并被早期采用。
