Hammerman C, Zaia W, Wu H H
Dev Pharmacol Ther. 1985;8(4):260-7. doi: 10.1159/000457045.
Five low-birth-weight neonates, ranging from 580 to 1,430 g, developed clinically significant hyponatremia (less than 130 mg/dl) within 48 h after being given indomethacin for patent ductus arteriosus closure. The extent of this hyponatremia is much more severe than previously reported. This group of infants is compared to another group of 5 patients who received indomethacin but did not develop severe hyponatremia. Several possible explanations for the observed differences are explored.
五名低体重新生儿，体重在580克至1430克之间，在使用吲哚美辛关闭动脉导管未闭后的48小时内出现了具有临床意义的低钠血症（低于130mg/dl）。这种低钠血症的程度比之前报道的要严重得多。将这组婴儿与另一组5名接受吲哚美辛治疗但未发生严重低钠血症的患者进行了比较。探讨了观察到的差异的几种可能解释。
