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韩国1型糖尿病患者群体中持续葡萄糖监测的使用现状——显著的年龄相关差异:全国队列研究

Current Status of Continuous Glucose Monitoring Use in South Korean Type 1 Diabetes Mellitus Population-Pronounced Age-Related Disparities: Nationwide Cohort Study.

作者信息

Kim Ji Yoon, Kim Seohyun, Kim Jae Hyeon

机构信息

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea.

出版信息

Diabetes Metab J. 2025 Sep;49(5):1040-1050. doi: 10.4093/dmj.2024.0804. Epub 2025 Apr 28.

Abstract

BACKGRUOUND

This study aims to identify the status of continuous glucose monitoring (CGM) use among individuals with type 1 diabetes mellitus (T1DM) in South Korea and to investigate whether age-related disparities exist.

METHODS

Individuals with T1DM receiving intensive insulin therapy were identified from the Korean National Health Insurance Cohort (2019-2022). Characteristics of CGM users and non-users were compared, and the prescription rates of CGM and sensor- augmented pump (SAP) or automated insulin delivery (AID) systems according to age groups (<19, 19-39, 40-59, and ≥60 years) were analyzed using chi-square tests. Glycosylated hemoglobin (HbA1c) levels and coefficients of variation (CV) among CGM users were also examined.

RESULTS

Among the 56,908 individuals with T1DM, 10,822 (19.0%) used CGM at least once, and 6,073 (10.7%) used CGM continuously. Only 241 (0.4%) individuals utilized either SAP or AID systems. CGM users were younger than non-users. The continuous prescription rate of CGM was highest among individuals aged <19 years (37.0%), followed by those aged 19-39 years (15.8%), 40-59 years (10.7%), and ≥60 years (3.9%) (P<0.001 for between-group differences). Among CGM users, HbA1c levels decreased from 8.7%±2.4% at baseline to 7.2%±1.2% at 24 months, and CV decreased from 36.6%±11.9% at 3 months to 34.1%±12.7% at 24 months.

CONCLUSION

Despite national reimbursement for CGM devices, the prescription rates of CGM remain low, particularly among older adults. Given the improvements in HbA1c and CV following CGM initiation, more efforts are needed to increase CGM utilization and reduce age-related disparities.

摘要

背景

本研究旨在确定韩国1型糖尿病(T1DM)患者中持续葡萄糖监测(CGM)的使用情况,并调查是否存在与年龄相关的差异。

方法

从韩国国民健康保险队列(2019 - 2022年)中识别接受强化胰岛素治疗的T1DM患者。比较CGM使用者和非使用者的特征,并使用卡方检验分析不同年龄组(<19岁、19 - 39岁、40 - 59岁和≥60岁)的CGM以及传感器增强泵(SAP)或自动胰岛素输送(AID)系统的处方率。还检查了CGM使用者的糖化血红蛋白(HbA1c)水平和变异系数(CV)。

结果

在56,908名T1DM患者中,10,822名(19.0%)至少使用过一次CGM,6,073名(10.7%)持续使用CGM。只有241名(0.4%)患者使用了SAP或AID系统。CGM使用者比非使用者年轻。CGM的持续处方率在<19岁的人群中最高(37.0%),其次是19 - 39岁的人群(15.8%)、40 - 59岁的人群(10.7%)和≥60岁的人群(3.9%)(组间差异P<0.001)。在CGM使用者中,HbA1c水平从基线时的8.7%±2.4%降至24个月时的7.2%±1.2%,CV从3个月时的36.6%±11.9%降至24个月时的34.1%±12.7%。

结论

尽管CGM设备已纳入国家医保报销范围,但CGM的处方率仍然较低,尤其是在老年人中。鉴于启动CGM后HbA1c和CV有所改善,需要做出更多努力来提高CGM的使用率并减少与年龄相关的差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a1e/12436030/d4381d87c475/dmj-2024-0804f1.jpg

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