J Cell Biochem. 2025 Apr;126(4):e70024. doi: 10.1002/jcb.70024.
W. Zhang, Y. Bi, Y. Wang, D. Li, N. He, M. Wang, J. Jin, Q. Zuo, Y. Zhang, and B. Li, "Nanos2 Promotes Differentiation of Chicken (Gallus gallus) Embryonic Stem Cells to Male Germ Cells," Journal of Cellular Biochemistry, 119, no. 6 (2018): 4435-4446, https://doi.org/10.1002/jcb.26528. The above article, published online on 16 November 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Christian Behl; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by third parties. Specifically, it was brought to the journal's attention that Nanos2 has not been identified in Gallus gallus. Further investigation confirmed that the gene examined in the article was actually Nos2, which encodes nitric oxide synthase 2 (NOS2), a protein with different and unrelated functions from those proposed in the study. The corresponding author B. Li stated that she did not directly participate in the experiments conducted for the study and was unaware of its submission. The corresponding author Y. Zhang, on behalf of the remaining co-authors, stated that they mistakenly assumed Nos2, which serves as an alias for Nanos2 in other species, to be homologous to Nanos2 in chickens. This misidentification undermines the study's rationale, methodology, and conclusions. Accordingly, the article is retracted.
张W、毕Y、王Y、李D、何N、王M、金J、左Q、张Y和李B，“Nanos2促进鸡胚胎干细胞向雄性生殖细胞分化”，《细胞生物化学杂志》，第119卷，第6期（2018年）：4435 - 4446页，https://doi.org/10.1002/jcb.26528 。上述文章于2017年11月16日在线发表于威利在线图书馆（wileyonlinelibrary.com），已根据作者、期刊主编克里斯蒂安·贝尔以及威利期刊有限责任公司之间的协议撤回。撤回是由于第三方提出的担忧。具体而言，有人提醒该期刊，在鸡中未鉴定出Nanos2。进一步调查证实，文章中检测的基因实际上是Nos2，它编码一氧化氮合酶2（NOS2），这是一种功能与该研究中提出的功能不同且不相关的蛋白质。通讯作者李B表示，她没有直接参与该研究进行的实验，也不知道文章的提交情况。通讯作者张Y代表其余共同作者表示，他们错误地认为在其他物种中作为Nanos2别名的Nos2与鸡中的Nanos2同源。这种错误识别破坏了该研究的基本原理、方法和结论。因此，该文章被撤回。
