Rodriguez Diana, Equilia Shirley, Roca Cristian, Ludi Erica, Espada Grover, García Zulma, Machuca Blanca, Clark Taryn, Gilman Robert H
School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.
Research Department, Universidad Cristiana de Bolivia, Santa Cruz, Bolivia.
J Glob Infect Dis. 2025 Mar 31;17(1):10-16. doi: 10.4103/jgid.jgid_130_24. eCollection 2025 Jan-Mar.
Antimicrobial resistance (AMR) is a growing threat to global public health. In hospitals, infant mortality due to bacterial sepsis is associated with AMR. The epidemiology of AMR in Bolivia (a lower-middle-income country) has not been sufficiently discussed. The aim of this study was to analyze AMR patterns over 8 years at a pediatric hospital in patients with hospital-acquired bloodstream infections.
This is a retrospective and analytical revision of AMR in bacteria isolated from blood cultures, performed between 2012 and 2019, in a pediatric hospital in Bolivia. Data analysis was conducted with Stata v14.0, and Fisher's exact tests were used to determine statistical significance.
Four hundred and fifty-five (7.2%) positive blood cultures were identified from 6315 blood culture reports between 2012 and 2019. was the most frequently isolated bacteria and showed a significant change in its AMR profile over the 8 years of the study. Gram-negative bacteria and were also frequently isolated, and all demonstrated high levels of resistance to commonly used antibiotics. Overall, most of the clinically important microorganisms had high rates of AMR.
In the present study, we report that isolated bacteria showed significant resistance to multiple drugs, and most demonstrated increased resistance over time. Worryingly, . showed an increasing resistance to commonly used antibiotics. Overall, despite the limitations, our study, which is one of the first of its kind in Bolivia, demonstrates the need for stricter policies of antibiotic stewardship in similar settings due to the global threat of AMR.
抗菌药物耐药性（AMR）对全球公共卫生构成的威胁日益严重。在医院中，细菌性败血症导致的婴儿死亡率与抗菌药物耐药性相关。玻利维亚（一个中低收入国家）抗菌药物耐药性的流行病学尚未得到充分讨论。本研究的目的是分析一家儿科医院8年来医院获得性血流感染患者的抗菌药物耐药模式。
这是一项对2012年至2019年期间在玻利维亚一家儿科医院从血培养中分离出的细菌的抗菌药物耐药性进行的回顾性分析修订。使用Stata v14.0进行数据分析，并使用Fisher精确检验确定统计学意义。
在2012年至2019年期间的6315份血培养报告中，共鉴定出455份（7.2%）阳性血培养。[此处原文缺失具体细菌名称]是最常分离出的细菌，并且在研究的8年中其抗菌药物耐药谱有显著变化。革兰氏阴性菌和[此处原文缺失具体细菌名称]也经常被分离出来，并且所有这些细菌对常用抗生素均表现出高水平耐药。总体而言，大多数具有临床重要性的微生物抗菌药物耐药率较高。
在本研究中，我们报告分离出的细菌对多种药物表现出显著耐药性，并且大多数随着时间推移耐药性增加。令人担忧的是，[此处原文缺失具体内容]对常用抗生素的耐药性呈上升趋势。总体而言，尽管存在局限性，但我们的研究作为玻利维亚同类研究中的首批研究之一，表明由于抗菌药物耐药性的全球威胁，在类似环境中需要更严格的抗生素管理政策。
