Texas A&M College of Medicine, 4257 Albans Street, Houston, TX 77005, USA.
Med Clin North Am. 2018 Sep;102(5):819-829. doi: 10.1016/j.mcna.2018.04.005. Epub 2018 Jun 27.
Antimicrobial resistance (AR) is one of the most serious public health threats today, which has been accelerated by the overuse and misuse of antimicrobials in humans and animals plus inadequate infection prevention. Numerous studies have shown a relationship between antimicrobial use and resistance. Antimicrobial stewardship (AS) programs have been shown to improve patient outcomes, reduce antimicrobial adverse events, and decrease AR. AS programs, when implemented alongside infection control measures, especially hand-hygiene interventions, were more effective than implementation of AS alone. Targeted coordination and prevention strategies are critical to stopping the spread of multidrug-resistant organisms.
抗菌药物耐药性（Antimicrobial Resistance，简称 AR）是当今最严重的公共卫生威胁之一，这主要是由于人类和动物对抗菌药物的过度和不当使用以及感染预防措施不足所导致的。大量研究表明，抗菌药物的使用与耐药性之间存在关联。抗菌药物管理（Antimicrobial Stewardship，简称 AS）计划已被证明可以改善患者的治疗效果，减少抗菌药物不良反应，并降低 AR 的发生率。当 AS 计划与感染控制措施（特别是手卫生干预措施）一起实施时，其效果优于单独实施 AS 计划。有针对性的协调和预防策略对于阻止多药耐药生物体的传播至关重要。
