替莫西林在肺组织中的渗透情况。

Lung tissue penetration of temocillin.

作者信息

Cowan W, Baird A, Sleigh J D, Gray J M, Leiper J M, Lawson D H

出版信息

Drugs. 1985;29 Suppl 5:151-3. doi: 10.2165/00003495-198500295-00031.

DOI:10.2165/00003495-198500295-00031

Abstract

Eight patients about to have the whole or part of a lung resected were given a 2g bolus dose of temocillin. A series of serum samples and a piece of peripheral lung tissue were collected and assayed for temocillin concentration. 30 minutes after drug administration, the mean serum and tissue concentrations were 172 mg/L and 45 mg/kg respectively.

摘要

八名即将接受全肺或部分肺切除的患者接受了2克替莫西林的大剂量注射。采集了一系列血清样本和一块外周肺组织，并检测替莫西林浓度。给药30分钟后，血清和组织的平均浓度分别为172毫克/升和45毫克/千克。