Cai Xiumei, Huang Suiping, Ma Zuliang
Xiumei Cai, Department of Medical Quality Control, Nanhai Affiliated Maternity and Children's Hospital of, Guangzhou University of Chinese Medicine, Foshan, China.
Suiping Huang, Department of Disease Prevention and Health Care, Shunde Hospital, Southern Medical University, The First People's Hospital of Shunde, Foshan, China.
Pak J Med Sci. 2025 Apr;41(4):952-957. doi: 10.12669/pjms.41.4.9578.
To investigate the effects of Hepatitis B virus (HBV) infection status on the outcomes of pregnancy.
A retrospective study was conducted at Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde) from 1 January 2020 to 31 December2022.The study included 13,980 pregnant women, with 1,059 in the HBsAg-positive group (study group) and 12,921 in the HBsAg-negative group (control group). Pregnancy outcomes were compared between the control and study groups.
Pregnant women who tested positive for HBsAg had higher rates of gestational diabetes mellitus (P=0.019; OR, 1.20; 95% CI, 1.03-1.40), intrahepatic cholestasis of pregnancy (P=0.019; OR, 1.85; 95% CI, 1.11-3.09) and preterm birth before 34 weeks (P=0.013; OR, 1.96; 95% CI, 1.15-3.34). The relationship between HBV infection status with gestational diabetes mellitus, intrahepatic cholestasis of pregnancy and preterm birth before 34 weeks was significant.
Pregnant women who tested positive for HBsAg faced a higher likelihood of developing gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, and giving birth prematurely before 34 weeks. Further clarification is required regarding the influence of HBV infection on the outcomes of pregnancy.
探讨乙型肝炎病毒（HBV）感染状态对妊娠结局的影响。
在南方医科大学顺德医院（佛山市顺德区第一人民医院）进行一项回顾性研究，研究时间为2020年1月1日至2022年12月31日。该研究纳入13980名孕妇，其中HBsAg阳性组（研究组）1059例，HBsAg阴性组（对照组）12921例。比较对照组和研究组的妊娠结局。
HBsAg检测呈阳性的孕妇患妊娠期糖尿病（P=0.019；OR，1.20；95%CI，1.03-1.40）、妊娠肝内胆汁淤积症（P=0.019；OR，1.85；95%CI，1.11-3.09）和34周前早产（P=0.013；OR，1.96；95%CI，1.15-3.34）的发生率更高。HBV感染状态与妊娠期糖尿病、妊娠肝内胆汁淤积症和34周前早产之间的关系显著。
HBsAg检测呈阳性的孕妇发生妊娠期糖尿病、妊娠肝内胆汁淤积症和34周前早产的可能性更高。关于HBV感染对妊娠结局的影响，还需要进一步阐明。
