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埃塞俄比亚东南部戈巴镇妊娠期糖尿病的发病率及危险因素:一项前瞻性队列研究。

Incidence and risk factors of gestational diabetes mellitus in Goba town, Southeast Ethiopia: a prospective cohort study.

机构信息

School of Medicine, Goba Referral Hospital, Madda Walabu University, Bale-Goba, Oromia, Ethiopia

School of Health Sciences, Goba Referral Hospital, Madda Walabu University, Bale-Goba, Oromia, Ethiopia.

出版信息

BMJ Open. 2022 Sep 26;12(9):e060694. doi: 10.1136/bmjopen-2021-060694.

Abstract

OBJECTIVE

Gestational diabetes mellitus (GDM) is becoming a public health concern in low/middle-income countries, and is known to cause severe morbidity and mortality for mothers and newborns. However, evidence reported for the incidence and risk factors of GDM is scant in Ethiopia. We aimed to assess the incidence of, and risk factors for, GDM in Goba town, Southeast Ethiopia.

DESIGN

Prospective cohort study.

SETTING

Goba town, Southeast Ethiopia.

PARTICIPANTS

Four hundred eighty pregnant women on antenatal care follow-up from 30 April to 30 September 2021.

PRIMARY AND SECONDARY OUTCOMES

Incidence and risk factors of GDM using fasting capillary blood glucose. Log-binomial model was used to identify the risk factors of GDM. Adjusted relative risk (aRR), along with 95% CIs, were calculated to estimate the strength of associations.

RESULTS

The cumulative incidence rate of GDM in this study was 15.7% (95% CI: 12.3% to 19.2%). Being unemployed (aRR=2.73; 95% CI: 1.36 to 5.47), having a family history of diabetes mellitus (DM) (3.01; 2.09 to 4.35), low physical activity (2.43; 1.11 to 5.32), inadequate dietary diversity (1.48; 1.29 to 1.92), anaemia (2.51; 1.32 to 3.54) and antenatal depression (4.95; 3.35 to 7.31) were significantly associated with GDM.

CONCLUSION

The cumulative incidence of GDM was relatively high among the study participants. Having antenatal depression symptoms, low physical activity, inadequate dietary diversity, being unemployed, anaemia and a family history of DM were significant risk factors for GDM.

摘要

目的

妊娠糖尿病(GDM)在中低收入国家成为一个公共卫生关注点,已知其会给母亲和新生儿带来严重的发病率和死亡率。然而,在埃塞俄比亚,有关 GDM 的发病率和危险因素的证据很少。我们旨在评估东南埃塞俄比亚戈巴镇 GDM 的发病率和危险因素。

设计

前瞻性队列研究。

地点

东南埃塞俄比亚戈巴镇。

参与者

2021 年 4 月 30 日至 9 月 30 日期间接受产前保健随访的 480 名孕妇。

主要和次要结果

使用空腹毛细血管血糖评估 GDM 的发病率和危险因素。使用对数二项式模型确定 GDM 的危险因素。计算调整后的相对风险(aRR)及其 95%CI,以估计关联的强度。

结果

本研究中 GDM 的累积发病率为 15.7%(95%CI:12.3%至 19.2%)。失业(aRR=2.73;95%CI:1.36 至 5.47)、有糖尿病家族史(DM)(3.01;2.09 至 4.35)、体力活动不足(2.43;1.11 至 5.32)、饮食多样性不足(1.48;1.29 至 1.92)、贫血(2.51;1.32 至 3.54)和产前抑郁(4.95;3.35 至 7.31)与 GDM 显著相关。

结论

研究参与者中 GDM 的累积发病率相对较高。产前抑郁症状、体力活动不足、饮食多样性不足、失业、贫血和 DM 家族史是 GDM 的显著危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a048/9516079/2792549b96ac/bmjopen-2021-060694f01.jpg

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