La Mantia Gaetano, Marcon Giulia, Coppini Martina, Buttacavoli Fortunato, Panzarella Vera, Colella Giuseppe, Capuano Annalisa, Sportiello Liberata, Parrinello Gaspare, Morreale Ilaria, Oteri Giacomo, Bellavia Giuseppe, Fusco Vittorio, Mauceri Rodolfo, Bazzano Monica, Seminara Giuseppe, Di Fede Olga, Campisi Giuseppina
Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy.
Unit of Oral Medicine and Dentistry for Fragile Patients, Department of Rehabilitation, Fragility, and Continuity of Care, University Hospital Palermo, Palermo, Italy.
Front Public Health. 2025 Apr 11;13:1572611. doi: 10.3389/fpubh.2025.1572611. eCollection 2025.
Pharmacovigilance plays a vital role in ensuring drug safety and protecting public health. Oropharyngeal adverse drug reactions (O-ADRs) are found to be under-reported, especially by oral health professionals, limiting the identification and management of these events.
This study aimed to evaluate the knowledge, attitudes, and practices (KAP) of healthcare professionals and students regarding O-ADRs and to assess their specific expertise by a self-e-learning test.
A cross-sectional survey was conducted using a KAP questionnaire between April 2023 and April 2024, involving 943 participants, including physicians, dentists, dental hygienists, and students. Additionally, three sets of self-e-learning tests on O-ADRs were administered. The study employed descriptive statistics, Kruskal-Wallis tests, and logistic regression to analyze factors affecting KAP and reporting behaviors.
Significant gaps in KAP were identified. Only 26.5% of participants demonstrated frequent best practices for reporting O-ADRs, with dentists and dental hygienists showing lower reporting rates (13.8% and 9.3%, respectively) compared to physicians (18.8%). The results of logistic regression analyses showed that practical knowledge was significantly associated with work experience (OR = 2.15, = 0.026). Students exhibited the lowest levels of practical knowledge and reporting proficiency, with only 17.6% demonstrating competence. The self-e-learning test highlighted knowledge deficits: only 22.9% of participants correctly identified O-ADR associated with antiseptic mouth rinses, additional 30.2% recognized those linked to antimicrobial drugs.
This study highlights the need for targeted educational interventions to address gaps in O-ADR knowledge and practice. Tailored training, user-friendly digital tools, and a strong pharmacovigilance culture are crucial for improving reporting rates and ensuring patient safety.
药物警戒在确保药物安全和保护公众健康方面发挥着至关重要的作用。据发现，口咽药物不良反应（O-ADRs）报告不足，尤其是口腔卫生专业人员，这限制了对这些事件的识别和管理。
本研究旨在评估医疗保健专业人员和学生关于O-ADRs的知识、态度和实践（KAP），并通过自我电子学习测试评估他们的专业知识。
在2023年4月至2024年4月期间，使用KAP问卷进行了一项横断面调查，涉及943名参与者，包括医生、牙医、口腔保健员和学生。此外，还进行了三组关于O-ADRs的自我电子学习测试。该研究采用描述性统计、Kruskal-Wallis检验和逻辑回归分析影响KAP和报告行为的因素。
在KAP方面发现了显著差距。只有26.5%的参与者表现出报告O-ADRs的频繁最佳实践，与医生（18.8%）相比，牙医和口腔保健员的报告率较低（分别为13.8%和9.3%）。逻辑回归分析结果表明，实践知识与工作经验显著相关（OR = 2.15，P = 0.026）。学生的实践知识和报告能力水平最低，只有17.6%的学生表现出能力。自我电子学习测试突出了知识缺陷：只有22.9%的参与者正确识别了与抗菌漱口水相关的O-ADR，另有30.2%的人识别出与抗菌药物相关的O-ADR。
本研究强调需要有针对性的教育干预措施来弥补O-ADR知识和实践方面的差距。量身定制的培训、用户友好的数字工具和强大的药物警戒文化对于提高报告率和确保患者安全至关重要。
