Mauceri Rodolfo, Arduini Sonia, Coppini Martina, Bazzano Monica, Trujillo Isabel, Campisi Giuseppina
Unit of Oral Medicine and Dentistry for Frail Patients, Department of Rehabilitation, Fragility and Continuity of Care, University Hospital Palermo, Palermo, Italy.
Department of Me.Pre.C.C., University of Palermo, Palermo, Italy.
Front Oral Health. 2024 Aug 1;5:1441601. doi: 10.3389/froh.2024.1441601. eCollection 2024.
Medication-related osteonecrosis of the Jaw (MRONJ) is an adverse drug reaction that affects the mandible and maxilla of patients exposed to BMA and AA therapies, causing the progressive destruction and death of bone. To date, oral health preventive measures remain the most effective strategy to reduce MRONJ incidence, and, in this sense, the major goal is to diagnose, treat, and eradicate any oral diseases that could compromise oral health. The present systematic review aims to investigate the awareness of MRONJ among patients assuming BMAs.
A systematic literature search was performed, selecting studies that concern the awareness of patients of the risk of MRONJ.
Six studies were included in this review. In total, 483 patients were evaluated. Of the 483 included patients, 391 were not aware of the possibility of MRONJ onset (391/483, 81%) and 92 were aware of it (92/483, 19%).
The problem of patient's lack of awareness with respect to MRONJ risk presents different layers of complexity ("what?", "who?", "where?", "when?" and "why?"). Among its causal factors, there are an inadequate level of communication with patients and the lack of collaboration between healthcare professionals, which is related to an individualistic view of liability and deontological duties. MRONJ is a drug adverse reaction that can greatly affect the quality of life of patients if not promptly diagnosed and treated. Therefore, patients must be fully aware of the risks of adverse and the importance of preventive measures, which imply effective and exhaustive communication by each member of the multidisciplinary team. Effective teamwork and collaborative care should be promoted to positively impact patients' awareness.
药物性颌骨坏死（MRONJ）是一种不良药物反应，会影响接受双膦酸盐类药物（BMA）和抗雄激素类药物（AA）治疗的患者的下颌骨和上颌骨，导致骨质进行性破坏和死亡。迄今为止，口腔健康预防措施仍然是降低MRONJ发病率的最有效策略，从这个意义上说，主要目标是诊断、治疗和根除任何可能损害口腔健康的口腔疾病。本系统评价旨在调查服用双膦酸盐类药物患者对MRONJ的认知情况。
进行了系统的文献检索，选择了有关患者对MRONJ风险认知情况的研究。
本评价纳入了6项研究。总共评估了483例患者。在纳入的483例患者中，391例未意识到发生MRONJ的可能性（391/483，81%），92例意识到了这一点（92/483，19%）。
患者对MRONJ风险缺乏认知的问题存在不同层面的复杂性（“是什么？”“谁？”“哪里？”“何时？”以及“为什么？”）。在其因果因素中，与患者的沟通水平不足以及医疗保健专业人员之间缺乏协作，这与对责任和道义责任的个人主义观点有关。MRONJ是一种药物不良反应，如果不及时诊断和治疗，会极大地影响患者的生活质量。因此，患者必须充分了解不良反应的风险以及预防措施的重要性，这意味着多学科团队的每个成员都要进行有效且详尽的沟通。应促进有效的团队合作和协作式护理，以积极影响患者的认知。
