衰老、排便障碍、睡眠障碍及非手术性脊柱感染：一项单中心回顾性分析

Senility, defecation disorders, sleep disorders, and non-operative spinal infections: A single-center retrospective analysis.

作者信息

Guo Ling-Ling, Liu Hong-Kun, Cao Jin-Feng, Zhang Hai-Xia, Li Bo, Li Tong, Li Liang

机构信息

Department of Orthopaedics of Integrated Traditional Chinese and Western Medicine, Zibo Central Hospital, Zibo 255000, Shandong Province, China.

Department of Radiology, Zibo Central Hospital, Zibo 255036, Shandong Province, China.

出版信息

World J Orthop. 2025 Apr 18;16(4):103388. doi: 10.5312/wjo.v16.i4.103388.

DOI:10.5312/wjo.v16.i4.103388

PMID:40290607

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12019144/

Abstract

BACKGROUND

Non-operative spinal infections (NOSI) are caused by tuberculosis, brucella, and other specific bacteria. The etiology of the disease is insidious, the onset is slow and the diagnosis and treatment are difficult. Identifying the factors associated with spinal infection and early intervention can reduce the occurrence of the disease. At present, the research mainly focuses on the accurate diagnosis and treatment of spinal infection, and there are few studies on the prevention of spinal infection. The concept of "preventive treatment of diseases" in traditional Chinese medicine may help identify the causes and reduce the occurrence of NOSI.

AIM

To determine the association of age, bowel movements, and sleep patterns with NOSI.

METHODS

Data of 69 NOSI patients and 84 healthy controls in a tertiary hospital from January 2019 to June 2024 were collected. Patients with NOSI had imaging evidence (magnetic resonance imaging) of spinal infections (including infections caused by tuberculosis, brucopathy, and other pathogens) and had no history of spinal surgery in the last 1 year were included in the analysis. Patients with spinal infection due to spinal surgery are excluded in the study. Data including age, sex, place of residence, sleeping status, and bowel movements were collected. SPSS22.0 was used for correlation analysis of all data.

RESULTS

The mean age of the NOSI group and the control group was 63.55 ± 14.635 years and 59.18 ± 17.111 years, respectively, without statistical difference ( = 0.096). There was also no statistically significant difference in gender between the two groups. In the NOSI group, 45 (65.22%) were over 60 years old, and 44 (63.77%) were rural residents. Compared with the control group, the NOSI group had more patients with sleep disorder and defecation disorder, accounting for 69.57% and 68.12%, respectively, with significant statistical difference (both < 0.001). Regression analysis showed that defecation and sleep disorders were closely related to NOSI (both < 0.001).

CONCLUSION

Most patients with NOSI are older and have sleep disorders and abnormal defecation.

摘要

背景

非手术性脊柱感染（NOSI）由结核、布鲁氏菌及其他特定细菌引起。该病病因隐匿，起病缓慢，诊断和治疗困难。识别与脊柱感染相关的因素并早期干预可减少该病的发生。目前，研究主要集中在脊柱感染的准确诊断和治疗上，而关于脊柱感染预防的研究较少。中医“治未病”理念可能有助于找出病因并减少NOSI的发生。

目的

确定年龄、排便情况和睡眠模式与NOSI的关联。

方法

收集了2019年1月至2024年6月某三级医院69例NOSI患者和84例健康对照的数据。纳入分析的NOSI患者有脊柱感染的影像学证据（磁共振成像）（包括结核、布鲁氏菌病及其他病原体引起的感染）且在过去1年无脊柱手术史。因脊柱手术导致脊柱感染的患者被排除在研究之外。收集了包括年龄、性别、居住地、睡眠状况和排便情况等数据。使用SPSS22.0对所有数据进行相关性分析。

结果

NOSI组和对照组的平均年龄分别为63.55±14.635岁和59.18±17.111岁，无统计学差异（P = 0.096）。两组性别也无统计学显著差异。在NOSI组中，45例（65.22%）年龄超过60岁，44例（63.77%）为农村居民。与对照组相比，NOSI组睡眠障碍和排便障碍患者更多，分别占69.57%和68.12%，有显著统计学差异（均P < 0.001）。回归分析表明，排便和睡眠障碍与NOSI密切相关（均P < 0.001）。