Qu Yaqian, Zhao Youliang
Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.
Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Front Nutr. 2025 Apr 11;12:1525408. doi: 10.3389/fnut.2025.1525408. eCollection 2025.
Pulmonary fibrosis is a fatal interstitial disease characterized by diffuse alveolitis, abnormal fibroblast proliferation, and extracellular matrix (ECM) accumulation, resulting in structural lung destruction and impaired lung function. Numerous studies have demonstrated that vitamins appear to play a crucial role in regulating inflammatory responses, cell differentiation, redox homeostasis, and collagen synthesis. Beyond their conventional nutritional functions, specific vitamins have recently been found to modulate various biological processes involved in pulmonary fibrosis. This study aims to provide a comprehensive overview of the current understanding regarding the impact of vitamins on pulmonary fibrotic disease.
肺纤维化是一种致命的间质性疾病，其特征为弥漫性肺泡炎、成纤维细胞异常增殖以及细胞外基质（ECM）积聚，导致肺结构破坏和肺功能受损。大量研究表明，维生素似乎在调节炎症反应、细胞分化、氧化还原稳态和胶原蛋白合成中发挥关键作用。除了其传统的营养功能外，最近还发现特定维生素可调节参与肺纤维化的各种生物学过程。本研究旨在全面概述目前对维生素对肺纤维化疾病影响的认识。
