Fessel Jeffrey
Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
J Alzheimers Dis Rep. 2025 Apr 15;9:25424823251335870. doi: 10.1177/25424823251335870. eCollection 2025 Jan-Dec.
There is need to understand the direct cause and, therefore, the appropriate treatment, of Alzheimer's disease (AD). A Google search was used to discern a) the primary cause of AD, and b) its treatment. Activation of Cdk5 is the primary cause for AD. Activation of Cdk5 may be decreased by using two drugs, roscovitine and tamoxifen, each having a different mechanism of action. Clinical trials should validate the efficacy and safety of using roscovitine and tamoxifen.
有必要了解阿尔茨海默病（AD）的直接病因以及相应的治疗方法。通过谷歌搜索来确定：a）AD的主要病因，以及b）其治疗方法。细胞周期蛋白依赖性激酶5（Cdk5）的激活是AD的主要病因。使用两种药物——罗可辛（roscovitine）和他莫昔芬（tamoxifen）可降低Cdk5的激活，这两种药物的作用机制不同。临床试验应验证使用罗可辛和他莫昔芬的疗效和安全性。
