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痛风:糖尿病患者中被忽视的疾病?一项丹麦前瞻性队列研究,随访2年。

Gout: An Overlooked Disease in Patients With Diabetes? A Danish Prospective Cohort Study With 2 Years of Follow-Up.

作者信息

Rasmussen Claus, Larsen Jesper Walther, Holm Peter C W, Nielsen Gunnar L

机构信息

Department of Rheumatology, North Denmark Regional Hospital, Hjørring, Denmark.

Center for Clinical Research, North Denmark Regional Hospital, Hjørring, Denmark.

出版信息

Clin Diabetes. 2025 Jan 6;43(2):282-290. doi: 10.2337/cd24-0082. eCollection 2025 Spring.

DOI:10.2337/cd24-0082
PMID:40290813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12019000/
Abstract

Diabetes affects approximately 6% of the population, with 20% developing foot ulcers. Gout affects about 3% of the population, but <40% receive sufficient urate-lowering therapy to prevent or dissolve urate crystal (tophi) deposition in the feet, which can ulcerate and become infected. Among patients with diabetes, 20% also have gout. This study aimed to assess adherence to recommended gout treatment in patients with diabetes and to compare usual care with initial care provided by a nurse-led gout care program. In patients with diabetes, gout is frequently undertreated, particularly when not initially managed in a nurse-led gout care program.

摘要

糖尿病影响着约6%的人口,其中20%会出现足部溃疡。痛风影响约3%的人口,但只有不到40%的患者接受足够的降尿酸治疗以预防或溶解尿酸盐结晶(痛风石)在足部的沉积,而这些结晶可能会溃疡并感染。在糖尿病患者中,20%也患有痛风。本研究旨在评估糖尿病患者对推荐的痛风治疗的依从性,并比较常规护理与由护士主导的痛风护理项目提供的初始护理。在糖尿病患者中,痛风常常治疗不足,尤其是在最初没有在护士主导的痛风护理项目中进行管理时。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a9d/12019000/41ab1d0de053/diaclincd240082f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a9d/12019000/41ab1d0de053/diaclincd240082f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a9d/12019000/41ab1d0de053/diaclincd240082f1.jpg

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本文引用的文献

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Adherence and Treat-to-Target Benchmarks in Older Adults With Gout Initiating Urate-Lowering Therapy in Ontario, Canada: A Population-Based Study.在加拿大安大略省,年龄较大的痛风患者开始使用尿酸降低疗法时的依从性和达标基准:一项基于人群的研究。
Arthritis Care Res (Hoboken). 2024 Oct;76(10):1379-1389. doi: 10.1002/acr.25380. Epub 2024 Jun 23.
2
Optimising gout treatment: insights from a nurse-led cohort study.优化痛风治疗:一项由护士主导的队列研究的见解
RMD Open. 2024 Apr 24;10(2):e004179. doi: 10.1136/rmdopen-2024-004179.
3
2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice.
2023 年 EULAR 关于在临床实践中应用影像学诊断和管理晶体相关性关节病的建议。
Ann Rheum Dis. 2024 May 15;83(6):752-759. doi: 10.1136/ard-2023-224771.
4
Association between serum urate and flares in people with gout and evidence for surrogate status: a secondary analysis of two randomised controlled trials.痛风患者血清尿酸与痛风发作之间的关联及替代指标地位的证据:两项随机对照试验的二次分析
Lancet Rheumatol. 2022 Jan;4(1):e53-e60. doi: 10.1016/S2665-9913(21)00319-2. Epub 2021 Nov 5.
5
4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Care in Diabetes-2024.4. 合并症的综合医学评估:2024年糖尿病护理标准
Diabetes Care. 2024 Jan 1;47(Suppl 1):S52-S76. doi: 10.2337/dc24-S004.
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Practical guidelines on the prevention and management of diabetes-related foot disease (IWGDF 2023 update).《糖尿病相关足部疾病预防与管理实用指南(IWGDF 2023 更新版)》。
Diabetes Metab Res Rev. 2024 Mar;40(3):e3657. doi: 10.1002/dmrr.3657. Epub 2023 May 27.
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JAMA. 2022 Aug 2;328(5):440-450. doi: 10.1001/jama.2022.11390.
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